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| Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium | |
Li, Meng1,2 ; Li, Caiwen1; Wang, Jinfeng1,2; Song, Shuqun1
| |
| 2015-05-01 | |
| 发表期刊 | MOLECULAR IMMUNOLOGY
 |
| 卷号 | 65期号:1页码:113-122 |
| 文章类型 | Article |
| 摘要 | The parasitic dinoflagellates in the genus of Hematodinium infect broad range of crustaceans around the world, causing fatal diseases in multiple species of wild and cultured crabs and subsequent economic loss. In order to explore this host parasite interaction in the early development stage of infection, mRNA transcript levels of eight key immune-related genes, including LGBP, proPO, PPAF, serpin, alpha 2m, and three PTcSPs were quantitatively assessed in Portunus trituberculatus artificially inoculated with the Hematodinium parasites. The fluctuation of proPO gene expression indicated that the host proPO system was disturbed overtly due to the intrusion of the parasites. And as manifested by the suppressed expression of LGBP and PPAF, an immunosuppressive mechanism was likely induced by the parasites against being entrapped or killed by the host proPO system. Furthermore, the significant variations of the transcript levels of serpin, alpha 2m, and the three PTcSPs suggested that the parasites affected the proteinase cascade reactions associated with the immune response by destroying the balance between serine proteinases and the proteinase inhibitors. The hemocytes counts and PO activity varied accordingly over the time course of infection, showing that hemocytes were actively involved in the immune response against the parasitic invasion. This study primarily highlighted the anti-parasitic immune response of crab hosts, and presented the first report of the immune response of P. trituberculatus to the parasitic dinoflagellate Hematodinium. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Portunus Trituberculatus Parasites Host Parasite Interaction Innate Immunity Gene Expression |
| DOI | 10.1016/j.molimm.2015.01.002 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350839500013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25413 |
| 专题 | 海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Meng,Li, Caiwen,Wang, Jinfeng,et al. Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium[J]. MOLECULAR IMMUNOLOGY,2015,65(1):113-122. |
| APA | Li, Meng,Li, Caiwen,Wang, Jinfeng,&Song, Shuqun.(2015).Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium.MOLECULAR IMMUNOLOGY,65(1),113-122. |
| MLA | Li, Meng,et al."Immune response and gene expression in hemocytes of Portunus trituberculatus inoculated with the parasitic dinoflagellate Hematodinium".MOLECULAR IMMUNOLOGY 65.1(2015):113-122. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Immune response and （3158KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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