| Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents | |
| Wang, Li-Jun; Wang, Shuai-Yu; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Wang, Bao-Cheng; Luo, Jiao; Yang, Meng; Jin, Shui-Hua; Shi, Da-Yong | |
| 2015-02-01 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 13期号:2页码:806-823 |
| 文章类型 | Article |
| 摘要 | A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g-4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure-activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs. |
| DOI | 10.3390/md13020806 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350217500008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25392 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Li-Jun,Wang, Shuai-Yu,Jiang, Bo,et al. Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents[J]. MARINE DRUGS,2015,13(2):806-823. |
| APA | Wang, Li-Jun.,Wang, Shuai-Yu.,Jiang, Bo.,Wu, Ning.,Li, Xiang-Qian.,...&Shi, Da-Yong.(2015).Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents.MARINE DRUGS,13(2),806-823. |
| MLA | Wang, Li-Jun,et al."Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents".MARINE DRUGS 13.2(2015):806-823. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Design, Synthesis an（1301KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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