| Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling | |
| Wu, Ning1; Luo, Jiao1; Jiang, Bo1; Wang, Lijun1; Wang, Shuaiyu1; Wang, Changhui2; Fu, Changqing2; Li, Jian2; Shi, Dayong1 | |
| 2015-02-01 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 13期号:2页码:1010-1025 |
| 文章类型 | Article |
| 摘要 | Bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a natural bromophenol compound derived from marine algae. Previous reports have shown that BDDPM possesses antimicrobial activity. In the present study, we found that BDDPM has cytotoxic activity on a wide range of tumor cells, including BEL-7402 cells (IC50 = 8.7 mu g/mL). Further studies have shown that prior to the onset of apoptosis, the BDDPM induces BEL-7402 cell detachment by decreasing the adherence of cells to the extracellular matrix (ECM). Detachment experiments have shown that the treatment of BEL-7402 cells with low concentrations of BDDPM (5.0 mu g/mL) significantly inhibits cell adhesion to fibronectin and collagen IV as well as cell migration and invasion. High doses of BDDPM (10.0 mu g/mL) completely inhibit the migration of BEL-7402 cells, and the expression level of MMPs (MMP-2 and MMP-9) is significantly decreased. Moreover, the expression of beta 1-integrin and focal adhesion kinase (FAK) is found to be down-regulated by BDDPM. This study suggests that BDDPM has a potential to be developed as a novel anticancer therapeutic agent due to its anti-metastatic activity and also indicates that BDDPM, which has a unique chemical structure, could serve as a lead compound for rational drug design and for future development of anticancer agents. |
| DOI | 10.3390/md13021010 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350217500020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/25389 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Med Univ, Affiliated Hosp, Qingdao 266070, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wu, Ning,Luo, Jiao,Jiang, Bo,et al. Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling[J]. MARINE DRUGS,2015,13(2):1010-1025. |
| APA | Wu, Ning.,Luo, Jiao.,Jiang, Bo.,Wang, Lijun.,Wang, Shuaiyu.,...&Shi, Dayong.(2015).Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling.MARINE DRUGS,13(2),1010-1025. |
| MLA | Wu, Ning,et al."Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling".MARINE DRUGS 13.2(2015):1010-1025. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Marine Bromophenol B（995KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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