| Genomic Analysis of the Pacific Oyster (Crassostrea gigas) Reveals Possible Conservation of Vertebrate Sex Determination in a Mollusc | |
| Zhang, Na1,2,3; Xu, Fei1; Guo, Ximing2; Guo, XM (reprint author), 6959 Miller Ave, Port Norris, NJ 08349 USA. | |
| 2014-11-01 | |
| 发表期刊 | G3-GENES GENOMES GENETICS
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| 卷号 | 4期号:11页码:2207-2217 |
| 文章类型 | Article |
| 摘要 | Despite the prevalence of sex in animal kingdom, we have only limited understanding of how sex is determined and evolved in many taxa. The mollusc Pacific oyster Crassostrea gigas exhibits complex modes of sexual reproduction that consists of protandric dioecy, sex change, and occasional hermaphroditism. This complex system is controlled by both environmental and genetic factors through unknown molecular mechanisms. In this study, we investigated genes related to sex-determining pathways in C. gigas through transcriptome sequencing and analysis of female and male gonads. Our analysis identified or confirmed novel homologs in the oyster of key sex-determining genes (SoxH or Sry-like and FoxL2) that were thought to be vertebrate-specific. Their expression profile in C. gigas is consistent with conserved roles in sex determination, under a proposed model where a novel testis-determining CgSoxH may serve as a primary regulator, directly or indirectly interacting with a testis-promoting CgDsx and an ovary-promoting CgFoxL2. Our findings plus previous results suggest that key vertebrate sex-determining genes such as Sry and FoxL2 may not be inventions of vertebrates. The presence of such genes in a mollusc with expression profiles consistent with expected roles in sex determination suggest that sex determination may be deeply conserved in animals, despite rapid evolution of the regulatory pathways that in C. gigas may involve both genetic and environmental factors. |
| 关键词 | Sex Determination Doublesex Sry Foxl2 Oyster Mollusca |
| 学科领域 | Genetics & Heredity |
| DOI | 10.1534/g3.114.013904 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345288700016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24218 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Guo, XM (reprint author), 6959 Miller Ave, Port Norris, NJ 08349 USA. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China 2.Rutgers State Univ, Inst Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Na,Xu, Fei,Guo, Ximing,et al. Genomic Analysis of the Pacific Oyster (Crassostrea gigas) Reveals Possible Conservation of Vertebrate Sex Determination in a Mollusc[J]. G3-GENES GENOMES GENETICS,2014,4(11):2207-2217. |
| APA | Zhang, Na,Xu, Fei,Guo, Ximing,&Guo, XM .(2014).Genomic Analysis of the Pacific Oyster (Crassostrea gigas) Reveals Possible Conservation of Vertebrate Sex Determination in a Mollusc.G3-GENES GENOMES GENETICS,4(11),2207-2217. |
| MLA | Zhang, Na,et al."Genomic Analysis of the Pacific Oyster (Crassostrea gigas) Reveals Possible Conservation of Vertebrate Sex Determination in a Mollusc".G3-GENES GENOMES GENETICS 4.11(2014):2207-2217. |
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