Phylogenetic and Biological Significance of Evolutionary Elements from Metazoan Mitochondrial Genomes

doi:10.1371/journal.pone.0084330

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	Phylogenetic and Biological Significance of Evolutionary Elements from Metazoan Mitochondrial Genomes
	Yuan, Jianbo 1,2,3; Zhu, Qingming 4; Liu, Bin 1,2,3; Liu, B (reprint author), Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Ctr Systemat Genom, Urumqi, Xinjiang, Peoples R China.
	2014-01-20
发表期刊	PLOS ONE
卷号	9 期号:1 页码:e84330
文章类型	Article
摘要	The evolutionary history of living species is usually inferred through the phylogenetic analysis of molecular and morphological information using various mathematical models. New challenges in phylogenetic analysis are centered mostly on the search for accurate and efficient methods to handle the huge amounts of sequence data generated from newer genome sequencing. The next major challenge is the determination of relationships between the evolution of structural elements and their functional implementation, which is largely ignored in previous analyses. Here, we described the discovery of structural elements in metazoan mitochondrial genomes, termed key K-strings, that can serve as a basis for phylogenetic tree construction. Although comprising only a small fraction (0.73%) of all K-strings, these key K-strings are pivotal to the tree construction because they allow for a significant reduction in the computational time required to construct phylogenetic trees, and more importantly, they make significant improvement to the results of phylogenetic inference. The trees constructed from the key K-strings were consistent overall to our current view of metazoan phylogeny and exhibited a more rational topology than the trees constructed by using other conventional methods. Surprisingly, the key K-strings tended to accumulate in the conserved regions of the original sequences, which were most likely due to strong selection pressure. Furthermore, the special structural features of the key K-strings should have some potential applications in the study of the structures and functions relationship of proteins and in the determination of evolutionary trajectory of species. The novelty and potential importance of key K-strings lead us to believe that they are essential evolutionary elements. As such, they may play important roles in the process of species evolution and their physical existence. Further studies could lead to discoveries regarding the relationship between evolution and processes of speciation.
学科领域	Science & Technology - Other Topics
DOI	10.1371/journal.pone.0084330
收录类别	SCI
语种	英语
WOS记录号	WOS:000330240500015
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24145
专题	实验海洋生物学重点实验室
通讯作者	Liu, B (reprint author), Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Ctr Systemat Genom, Urumqi, Xinjiang, Peoples R China.
作者单位	1.Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Ctr Systemat Genom, Urumqi, Xinjiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 4.GenomeSense Inst, Beijing, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yuan, Jianbo,Zhu, Qingming,Liu, Bin,et al. Phylogenetic and Biological Significance of Evolutionary Elements from Metazoan Mitochondrial Genomes[J]. PLOS ONE,2014,9(1):e84330.
APA	Yuan, Jianbo,Zhu, Qingming,Liu, Bin,&Liu, B .(2014).Phylogenetic and Biological Significance of Evolutionary Elements from Metazoan Mitochondrial Genomes.PLOS ONE,9(1),e84330.
MLA	Yuan, Jianbo,et al."Phylogenetic and Biological Significance of Evolutionary Elements from Metazoan Mitochondrial Genomes".PLOS ONE 9.1(2014):e84330.

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