Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms

doi:10.1371/journal.pone.0091606

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	Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
	Liu, Jia 1,2; Wu, Ning 1; Ma, Leina 4; Liu, Ming 1; Liu, Ge 1,2; Zhang, Yuyan 1; Lin, Xiukun 1,3; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China.
	2014-03-13
发表期刊	PLOS ONE
卷号	9 期号:3 页码:e91606
文章类型	Article
摘要	Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis. In recent years, increased expression level of pyruvate kinase M2 (PKM2) has been found to be the culprit of enhanced aerobic glycolysis in cancer cells. However, there is no agent inhibiting aerobic glycolysis by targeting PKM2. In this study, we found that Oleanolic acid (OA) induced a switch from PKM2 to PKM1, and consistently, abrogated Warburg effect in cancer cells. Suppression of aerobic glycolysis by OA is mediated by PKM2/PKM1 switch. Furthermore, mTOR signaling was found to be inactivated in OA-treated cancer cells, and mTOR inhibition is required for the effect of OA on PKM2/PKM1 switch. Decreased expression of c-Myc-dependent hnRNPA1 and hnRNPA1 was responsible for OA-induced switch between PKM isoforms. Collectively, we identified that OA is an antitumor compound that suppresses aerobic glycolysis in cancer cells and there is potential that PKM2 may be developed as an important target in aerobic glycolysis pathway for developing novel anticancer agents.
学科领域	Science & Technology - Other Topics
DOI	10.1371/journal.pone.0091606
收录类别	SCI
语种	英语
WOS记录号	WOS:000332851300107
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24140
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Dept Mol Biol, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Jia,Wu, Ning,Ma, Leina,et al. Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms[J]. PLOS ONE,2014,9(3):e91606.
APA	Liu, Jia.,Wu, Ning.,Ma, Leina.,Liu, Ming.,Liu, Ge.,...&Lin, XK .(2014).Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms.PLOS ONE,9(3),e91606.
MLA	Liu, Jia,et al."Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms".PLOS ONE 9.3(2014):e91606.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Oleanolic Acid Suppr（1769KB）			限制开放	ODC PDDL	浏览