Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy

doi:10.1016/j.jnutbio.2014.06.006

IOCAS-IR > 实验海洋生物学重点实验室

	Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy
	Liu, Jia 1,3; Zheng, Lanhong 2; Ma, Leina 4; Wang, Bin5 ; Zhao, Youguang 6; Wu, Ning 3; Liu, Ge 3; Lin, Xiukun 3,7; Lin, XK (reprint author), Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China.
	2014-11-01
发表期刊	JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷号	25 期号:11 页码:1154-1160
文章类型	Article
摘要	Oleanolic acid (OA) has been widely studied because of its pleiotropic therapeutic and preventive effect on various diseases. However, the mechanisms of OA's action are still not clear yet, especially its suppressing effect on transformed cells. In this work, we found that OA induced autophagy in normal tissue-derived cells without cytotoxicity. OA-induced autophagy was shown to decrease the proliferation of KRAS-transformed normal cells and to impair their invasion and anchorage-independent growth. Interrupting autophagy rescued OA's effect on the transformed cells. Mouse model experiments also demonstrated that OA suppressed the growth of KRAS-transformed breast epithelial cell MCF10A-derived tumor xenograft by inducing autophagy. Finally, we identified that OA induced autophagy in normal cells by inhibiting the activation of Akt/mTOR/S6K signaling. In conclusions, we found that OA treatment permitted normal cells to undergo autophagy. The induced autophagy was required for OA to prevent or delay the growth of transformed normal cells. (C) 2014 Published by Elsevier Inc.
关键词	Oleanolic Acid Autophagy Akt Cancer Prevention Natural Compounds
学科领域	Biochemistry & Molecular Biology ; Nutrition & Dietetics
DOI	10.1016/j.jnutbio.2014.06.006
收录类别	SCI
语种	英语
WOS记录号	WOS:000344205600007
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24139
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China.
作者单位	1.Qingdao Univ, Coll Med, Qingdao 266021, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Dept Mol Biol, Qingdao 266003, Peoples R China 5.Third Militaty Med Univ, Daping Hosp, Inst Surg Res, Dept Gastroenterol, Chongqing 400042, Peoples R China 6.Chinese PLA, Chengdu Mil Area Command, Gen Hosp, Dept Urol, Chengdu 610083, Peoples R China 7.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Jia,Zheng, Lanhong,Ma, Leina,et al. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2014,25(11):1154-1160.
APA	Liu, Jia.,Zheng, Lanhong.,Ma, Leina.,Wang, Bin.,Zhao, Youguang.,...&Lin, XK .(2014).Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,25(11),1154-1160.
MLA	Liu, Jia,et al."Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25.11(2014):1154-1160.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Oleanolic acid inhib（926KB）			限制开放	ODC PDDL	浏览