Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway

doi:10.1021/jf500622p

IOCAS-IR > 实验海洋生物学重点实验室

	Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway
	Liu, Jia 1,3; Zheng, Lanhong 2; Wu, Ning 1; Ma, Leina 4; Zhong, Jiateng 5; Liu, Ge 1,3; Lin, Xiukun 1,6; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
	2014-06-18
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号	62 期号:24 页码:5528-5537
文章类型	Article
摘要	Cancer cells are well-known to require a constant supply of protein, lipid, RNA, and DNA via altered metabolism for accelerated cell proliferation. Targeting metabolic pathways is, therefore, a promising therapeutic strategy for cancers. Oleanolic acid (OA) is widely distributed in dietary and medicinal plants and displays a selective cytotoxicity to cancer cells, primarily by inducing apoptosis and cell cycle arrest. This study investigated if OA inhibited growth of tumor cells by affecting their metabolism. OA was found to activate AMP-activated protein kinase (AMPK), the master regulator of metabolism, in prostate cancer cell line PC-3 and breast cancer cell line MCF-7. AMPK activation is required for the antitumor activity of OA on cancer cells. Lipogenesis, protein synthesis, and aerobic glycolysis were inhibited in cancer cells treated with OA, in an AMPK activation-dependent manner. The metabolic alteration was shown to mediate the tumor suppressor activity of OA on cancer cells. Collectively, this study provides evidence that OA, as a widely distributed nutritional component, is able to exert antitumor function by interfering in the metabolic pathway in cancer cells. This finding should encourage researchers to study if affecting cancer metabolism is a common mechanism by which nutritional compounds suppress cancers.
关键词	Aerobic Glycolysis Ampk Metabolism Oleanolic Acid
学科领域	Agriculture ; Chemistry ; Food Science & Technology
DOI	10.1021/jf500622p
收录类别	SCI
语种	英语
WOS记录号	WOS:000337720100016
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24137
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China 5.Jilin Univ, Dept Pathophysiol, Norman Bethune Coll Med, Changchun 130021, Peoples R China 6.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Jia,Zheng, Lanhong,Wu, Ning,et al. Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014,62(24):5528-5537.
APA	Liu, Jia.,Zheng, Lanhong.,Wu, Ning.,Ma, Leina.,Zhong, Jiateng.,...&Lin, XK .(2014).Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,62(24),5528-5537.
MLA	Liu, Jia,et al."Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62.24(2014):5528-5537.

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