Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection

doi:10.1016/j.fsi.2023.109282

IOCAS-IR > 实验海洋生物学重点实验室

	Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection
	Miao, Miao1,2 ; Li, Shihao 1,3,4; Yu, Yang1,4 ; Liu, Yuan 1,4; Li, Fuhua 1,3,4,5
	2024
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	144 页码:10
通讯作者	Li, Fuhua([email protected])
摘要	Vibrio parahaemolyticus carrying a pathogenic plasmid (VPAHPND) is one of the main causative agents of acute hepatopancreatic necrosis disease (AHPND) in shrimp aquaculture. Knowledge about the mechanism of shrimp resistant to VPAHPND is very helpful for developing efficient strategy for breeding AHPND resistant shrimp. In order to learn the mechanism of shrimp resistant to AHPND, comparative transcriptome was applied to analyze the different expressions of genes in the hepatopancreas of shrimp from different families with different resistance to VPAHPND. Through comparative analysis on the hepatopancreas of shrimp from VPAHPND resistant family and susceptible family, we found that differentially expressed genes (DEGs) were mainly involved in immune and metabolic processes. Most of the immune-related genes among DEGs were highly expressed in the hepatopancreas of shrimp from resistant family, involved in recognition of pathogen-associated molecular patterns, phagocytosis and elimination of pathogens, maintenance of reactive oxygen species homeostasis and other immune processes etc. However, most metabolic-related genes were highly expressed in the hepatopancreas of shrimp from susceptible family, involved in metabolism of lipid, vitamin, cofactors, glucose, carbohydrate and serine. Interestingly, when we analyzed the expression of above DEGs in the shrimp after VPAHPND infection, we found that the most of identified immune-related genes remained at high expression levels in the hepatopancreas of shrimp from the VPAHPND resistant family, and most of the identified metabolic-related genes were still at high expression levels in the hepatopancreas of shrimp from the VPAHPND susceptible family. The data suggested that the differential expression of these immune-related and metabolic-related genes in hepatopancreas might contribute to the resistance variations of shrimp to VPAHPND. These results provided valuable information for understanding the resistant mechanism of shrimp to VPAHPND.
关键词	Litopenaeus vannamei Vibrio parahaemolyticus Disease resistance Immune-related genes Metabolic-related genes
DOI	10.1016/j.fsi.2023.109282
收录类别	SCI
语种	英语
资助项目	Key Program of National Natural Science Foundation of China[31830100]; National Key Research and Development Program of China[2022YFD2400203]; Earmarked fund for CARS-48; Taishan Scholars Program
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:001138384100001
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS关键词	C-TYPE LECTIN ; LITOPENAEUS-VANNAMEI ; CHINESE SHRIMP ; NECROSIS DISEASE ; INNATE IMMUNITY ; ATP-SYNTHASE ; PROTEIN ; SERINE ; RECOGNITION ; AHPND
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/199657
专题	实验海洋生物学重点实验室
通讯作者	Li, Fuhua
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Miao, Miao,Li, Shihao,Yu, Yang,et al. Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection[J]. FISH & SHELLFISH IMMUNOLOGY,2024,144:10.
APA	Miao, Miao,Li, Shihao,Yu, Yang,Liu, Yuan,&Li, Fuhua.(2024).Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection.FISH & SHELLFISH IMMUNOLOGY,144,10.
MLA	Miao, Miao,et al."Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection".FISH & SHELLFISH IMMUNOLOGY 144(2024):10.