Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus <i>Aplosporella javeedii</i> using OSMAC strategy

doi:10.3389/fmicb.2024.1458622

IOCAS-IR > 实验海洋生物学重点实验室

	*Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii* using OSMAC strategy**
	Gao, Ying 1,2; Frank, Marian 2; Teusch, Nicole 2; Woschko, Dennis 3; Janiak, Christoph 3; Mandi, Attila 4; Kurtan, Tibor 4; Hartmann, Rudolf 5; Schiedlauske, Katja 2; van Geelen, Lasse 2; Kalscheuer, Rainer 2; Kaiser, Jesko 6; Gertzen, Christoph G. W.6; Gohlke, Holger 6,7; Wang, Bin-Gui8,9 ; Proksch, Peter 2; Liu, Zhen 1
	2024-09-27
发表期刊	FRONTIERS IN MICROBIOLOGY
卷号	15 页码:10
通讯作者	Proksch, Peter([email protected]) ; Liu, Zhen([email protected])
摘要	Three sulfur-containing alkaloids aplospojaveedins A-C (1-3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, alpha, beta-unsaturated lactam and glycine-cysteine moieties were isolated from Aplosporella javeedii. Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1-3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin alpha 5 beta 1 complex.
关键词	Aplosporella javeedii alkaloids OSMAC approach X-ray diffraction DFT-NMR calculations TDDFT-ECD calculations target prediction
DOI	10.3389/fmicb.2024.1458622
收录类别	SCI
语种	英语
资助项目	Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[INST 208/589-1]; National Research Development and Innovation Office[K-138672]; National Research Development and Innovation Office[FK-134653]; Deutsche Forschungsgemeinschaft [DFG, German Research Foundation][270650915/GRK 2158]; Hunan Provincial Natural Science Foundation of China[2022JJ40286]; Changsha Municipal Natural Science Foundation[kq2202257]; Intra Institutional Open Fund of School of Medicine, Hunan Normal University[KF2022001]
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001336664800001
出版者	FRONTIERS MEDIA SA
WOS关键词	CRYSTAL-STRUCTURE ; ACTIVATION ; DOCKING ; IDENTIFICATION ; INHIBITORS ; EQUISETIN ; BINDING
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/199499
专题	实验海洋生物学重点实验室
通讯作者	Proksch, Peter; Liu, Zhen
作者单位	1.Hunan Normal Univ, Sch Med, Key Lab Study & Discovery Small Targeted Mol Hunan, Changsha, Peoples R China 2.Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, Dusseldorf, Germany 3.Heinrich Heine Univ, Inst Inorgan & Struct Chem, Dusseldorf, Germany 4.Univ Debrecen, Dept Organ Chem, Debrecen, Hungary 5.Forschungszentrum Julich, Inst Biol Informat Proc Struct Biochem IBI 7, Julich, Germany 6.Heinrich Heine Univ, Inst Pharmaceut & Med Chem, Dusseldorf, Germany 7.Forschungszentrum Julich, Inst Bioand Geosci IBG 4 Bioinformat, Julich, Germany 8.Chinese Acad Sci, Inst Oceanol, CAS, Qingdao, Peoples R China 9.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Gao, Ying,Frank, Marian,Teusch, Nicole,et al. Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy[J]. FRONTIERS IN MICROBIOLOGY,2024,15:10.
APA	Gao, Ying.,Frank, Marian.,Teusch, Nicole.,Woschko, Dennis.,Janiak, Christoph.,...&Liu, Zhen.(2024).Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy.FRONTIERS IN MICROBIOLOGY,15,10.
MLA	Gao, Ying,et al."Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy".FRONTIERS IN MICROBIOLOGY 15(2024):10.