Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters

doi:10.1186/s12964-024-01923-0

IOCAS-IR > 实验海洋生物学重点实验室

	Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters
	Wang, Chaogang1,3,5 ; Jiang, Zhuxiang 3,5,6; Du, Mingyang 3,5,6; Cong, Rihao 2,3,5,8; Wang, Wei 3,4,5; Zhang, Taiping 3,5,6; Chen, Jincheng 3,5,6; Zhang, Guofan 1,2,3,5,7,8; Li, Li 1,3,4,5,6,7
	2024-11-11
发表期刊	CELL COMMUNICATION AND SIGNALING
卷号	22 期号:1 页码:27
通讯作者	Li, Li([email protected])
摘要	Phosphorylation of Ser32 and Ser36 controls the degradation of I kappa B alpha is the conserved cascade mechanisms of immune core signaling pathway, NF-kappa B pathway in metazoans, but it's response to abiotic stress and the presence of novel phosphorylation mechanisms in other species remain unclear. Herein, we reported a novel heat-induced phosphorylation site (Ser74) at oysters' major I kappa B alpha, which independently regulated ubiquitination-proteasome degradation without the requirement of phosphorylation at S32 and S36. And this site was phosphorylated by ERK/MAPK pathway, which then promoted REL nuclear translocation to activate cell survival related genes to defend heat-stress. The MAPK-NF-kappa B cascade exhibited divergent thermal responses and adaptation patterns between two congeneric oyster species with differential habitat temperatures, indicating its involvement in shaping temperature adaptation. This study demonstrated that the existence of complex and unique phosphorylation-mediated signaling transduction mechanism in marine invertebrates, and expanded our understanding of the evolution and function of established classical pathway crosstalk mechanisms.
关键词	NF-kappa B pathway MAPK pathway I kappa B alpha ERK Temperature Adaptation Oysters
DOI	10.1186/s12964-024-01923-0
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2022YFD2400304]; Key Research and Development Program of Shandong[2022LZGC015]; Key Research and Development Program of Shandong[ZFJH202309]; China Agriculture Research System of MOF[CARS-49]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:001352447400002
出版者	BMC
WOS关键词	NATIVE MYTILUS-CALIFORNIANUS ; ACTIVATED PROTEIN-KINASE ; MOLECULAR CHARACTERIZATION ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; HEAT-SHOCK ; EXPRESSION ; GALLOPROVINCIALIS ; GENES ; ERK
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/199424
专题	实验海洋生物学重点实验室
通讯作者	Li, Li
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 5.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao, Peoples R China 8.Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chaogang,Jiang, Zhuxiang,Du, Mingyang,et al. Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters[J]. CELL COMMUNICATION AND SIGNALING,2024,22(1):27.
APA	Wang, Chaogang.,Jiang, Zhuxiang.,Du, Mingyang.,Cong, Rihao.,Wang, Wei.,...&Li, Li.(2024).Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.CELL COMMUNICATION AND SIGNALING,22(1),27.
MLA	Wang, Chaogang,et al."Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters".CELL COMMUNICATION AND SIGNALING 22.1(2024):27.