Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo

doi:10.1016/j.colsurfb.2024.114343

IOCAS-IR > 实验海洋生物学重点实验室

	Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo
	Jiang, Tao1 ; Zhu, Feikai 1; Gao, Xintao 1; Wu, Xiaochen 1; Zhu, Wenyong 2; Guo, Chuanlong 1,3
	2025
发表期刊	COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN	0927-7765
卷号	245 页码:10
通讯作者	Zhu, Wenyong([email protected]) ; Guo, Chuanlong([email protected])
摘要	Acute kidney injury (AKI) is a common clinical problem with no effective treatment. Excessive folic acid (FA) induced kidney tubular injury is characterized by oxidative stress and inflammation, and is a common model of AKI. The excellent pharmacological activity of naringenin (NAR) makes it a potential agent for treating AKI, but its poor solubility limits its application. This study prepared NAR loaded nanoparticles (FU/PVP-NAR) using fucoidan (FU) and polyvinylpyrrolidone (PVP) as carriers, with a particle size of 23.96 +/- 2.77 nm. In vitro studies showed that FU/PVP-NAR inhibited excessive FA induced proliferation inhibition, accumulation of reactive oxygen species (ROS), and disruption of mitochondrial membrane potential (MMP) of HK-2 cells. Further confirmed that FU/PVP-NAR inhibited FA induced DNA damage and Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation. In vivo studies showed that excessive FA induced AKI features in mice, such as elevated serum creatinine (SCr) and blood urea nitrogen (BUN) levels, accompanied by pathological damage to kidney tissues. The above AKI characteristics induced by FA were alleviated by FU/PVP-NAR. FU/PVP-NAR also inhibited the decrease in antioxidant enzyme levels in kidney tissues induced by FA. Furthermore, in vivo mechanism studies indicated that FU/PVP-NAR inhibited the release of inflammatory factors by inhibiting DNA damage-cGAS-STING pathway. In summary, this study provided the possibility for FU/PVPNAR as a potential candidate drug for treating FA induced AKI.
关键词	Acute kidney injury Folic acid Naringenin CGAS-STING
DOI	10.1016/j.colsurfb.2024.114343
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[22307060]; Shandong Provincial Natural Science Foundation[ZR2020QH359]; Open Fund of CAS; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06]
WOS研究方向	Biophysics ; Chemistry ; Materials Science
WOS类目	Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS记录号	WOS:001349575300001
出版者	ELSEVIER
WOS关键词	DNA-DAMAGE ; INFLAMMATION ; NEPHROTOXICITY ; CONSEQUENCES ; ACTIVATION
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/199391
专题	实验海洋生物学重点实验室
通讯作者	Zhu, Wenyong; Guo, Chuanlong
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Shandong Univ, Qilu Hosp Qingdao, Cheeloo Coll Med, Dept Thorac Surg, Qingdao 266035, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Tao,Zhu, Feikai,Gao, Xintao,et al. Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2025,245:10.
APA	Jiang, Tao,Zhu, Feikai,Gao, Xintao,Wu, Xiaochen,Zhu, Wenyong,&Guo, Chuanlong.(2025).Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.COLLOIDS AND SURFACES B-BIOINTERFACES,245,10.
MLA	Jiang, Tao,et al."Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo".COLLOIDS AND SURFACES B-BIOINTERFACES 245(2025):10.