Population genomic analysis reveals a polygenic sex determination system in <i>Apostichopus japonicus</i>

doi:10.1016/j.isci.2024.110852

	Population genomic analysis reveals a polygenic sex determination system in Apostichopus japonicus
	Jiang, Chunxi 1,2,3,4; Liu, Shilin 1,2,3,4; Yang, Yujia 5; Cui, Wei1,2,3,4 ; Xu, Shuai1,2,3,4 ; Rasoamananto, Irene 6; Lavitra, Thierry 6; Zhang, Libin 1,2,3,4; Sun, Lina 1,2,3,4
	2024-10-18
发表期刊	ISCIENCE
卷号	27 期号:10 页码:16
通讯作者	Sun, Lina([email protected])
摘要	The sea cucumber Apostichopus japonicus , , a key species in Chinese aquaculture, plays a significant evolutionary role within the Echinodermata phylum. However, the sex determination mechanism in this species remains poorly understood. Here, we conducted extensive sex surveys and sampling of eight wild populations, investigating the sex-related SNPs and insertion or deletions (indels) through bulk segregation analysis (BSA) and genome-wide association study (GWAS) analysis. Our findings suggest that A. japonicus employs a polygenic sex determination (PSD) system, with solute carrier family 8 (SLC8A) being the candidate gene for sex determination, encoding sodium-calcium exchanger (NCX1). The analysis of normalized sequencing depth reveals variations across chromosomes 6,13,14, 16, and 18, supporting the PSD system. We also identified 541.656 kb of male-specific sequences and screened five markers (C77185, C98086, C64977, C125, and C876) for molecular sex identification. Overall, this study provides new insights into A. japonicus sex determination, highlighting a complex multi-gene mechanism rather than a simple XX/XY system.
DOI	10.1016/j.isci.2024.110852
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2022YFE0140900]; Key Research and Development Program of Shan-dong[2021LZGC029]; National Natural Science Foundation of China[42206084]; Taishan Scholars Program[tsqn202306279]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001320826300001
出版者	CELL PRESS
WOS关键词	DNA ; CHROMOSOMES
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/199247
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao, Peoples R China 6.Univ Toliara, Inst Halieut & Sci Marines IHSM, Toliara, Madagascar
推荐引用方式 GB/T 7714	Jiang, Chunxi,Liu, Shilin,Yang, Yujia,et al. Population genomic analysis reveals a polygenic sex determination system in Apostichopus japonicus[J]. ISCIENCE,2024,27(10):16.
APA	Jiang, Chunxi.,Liu, Shilin.,Yang, Yujia.,Cui, Wei.,Xu, Shuai.,...&Sun, Lina.(2024).Population genomic analysis reveals a polygenic sex determination system in Apostichopus japonicus.ISCIENCE,27(10),16.
MLA	Jiang, Chunxi,et al."Population genomic analysis reveals a polygenic sex determination system in Apostichopus japonicus".ISCIENCE 27.10(2024):16.