Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo

doi:10.1016/j.fct.2023.114427

IOCAS-IR > 实验海洋生物学重点实验室

	Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo
	Zhou, Shilin 1; Sun, Yuxuan 1; Wang, Kaidi 1; Gao, Xintao 1; Dong, Kehong 1; Wang, Jing2 ; Wu, Xiaochen 1; Guo, Chuanlong 1,3
	2024-02-01
发表期刊	FOOD AND CHEMICAL TOXICOLOGY
ISSN	0278-6915
卷号	184 页码:11
通讯作者	Wu, Xiaochen([email protected]) ; Guo, Chuanlong([email protected])
摘要	Oxaliplatin (OXL) is a first-line drug for the treatment of colon cancer, with excellent efficacy. Intestinal toxicity is a common side effect of OXL, with unclear pathogenesis and a lack of effective treatment strategies. Polydatin (PD) has anti-inflammatory and antioxidant activities and is a potential drug for treating intestinal diseases, but its poor water solubility limits its application. In this study, polyvinylpyrrolidone (PVP) was used as a carrier to prepare nanoparticles loaded with PD (PVP-PD), with a particle size of 92.42 nm and exhibiting sustained release properties. In vitro results showed that PVP-PD protected NCM460 cells from OXL induced injury, mitochondrial membrane potential (MMP) disruption, and accumulation of reactive oxygen species (ROS). The in vivo results demonstrated the protective effect of PVP-PD on intestinal toxicity induced by OXL, such as alleviating weight loss and colon length reduction induced by OXL. Both in vivo and in vitro mechanisms indicated that OXL induced DNA damage and activated the cGAS-STING pathway, further inducing the expression of inflammatory factors such as IL-1 beta and TNF-alpha. PVP-PD alleviated the aforementioned changes induced by OXL by inhibiting the DNA damage-cGAS-STING pathway. In summary, our study demonstrated that the DNA damage-cGAS-STING pathway was involved in OXL induced intestinal toxicity, and PVP-PD provided a potential strategy for treating OXL induced intestinal toxicity.
关键词	Oxaliplatin Intestinal toxicity Polydatin DNA damage cGAS-STING
DOI	10.1016/j.fct.2023.114427
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[22307060]; Shandong Provincial Natural Science Foundation[ZR2020QH359]; Open Fund of CAS; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06]; Program for Young Talents of Science and Technology in Universities of Inner Mongolia[NJYT-18-B29]; Doctoral Scientific Research Foundation of Inner Mongolia[BTTCRCQD2018001]
WOS研究方向	Food Science & Technology ; Toxicology
WOS类目	Food Science & Technology ; Toxicology
WOS记录号	WOS:001298946100001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	CHEMOTHERAPY-INDUCED NAUSEA ; OXIDATIVE STRESS ; STING PATHWAY ; CGAS ; DNA ; CANCER ; INJURY ; 2ND-MESSENGER ; SENESCENCE ; MANAGEMENT
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/198168
专题	实验海洋生物学重点实验室
通讯作者	Wu, Xiaochen; Guo, Chuanlong
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Peoples R China 2.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China 3.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Shilin,Sun, Yuxuan,Wang, Kaidi,et al. Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2024,184:11.
APA	Zhou, Shilin.,Sun, Yuxuan.,Wang, Kaidi.,Gao, Xintao.,Dong, Kehong.,...&Guo, Chuanlong.(2024).Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,184,11.
MLA	Zhou, Shilin,et al."Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 184(2024):11.