The preparation and antioxidant activity of glucosamine sulfate

IOCAS-IR

	The preparation and antioxidant activity of glucosamine sulfate
	Xing RE(邢荣娥); Liu S(刘松); Wang L(王琳); Cai SB(蔡圣宝); Yu HH(于华华); Feng JH(冯金华); Li PC(李鹏程)
发表期刊	Chinese Journal of Oceanology and Limnology
ISSN	0254-4059
	2009-05-15
出版年	2009
卷号	v.27 期号:02 页码:101-105
文献类型	CNKI期刊论文
摘要	Glucosamine sulfate was prepared from glucosamine hydrochloride that was produced by acidic hydrolysis of chitin by ion-exchange method. Optical rotation and elemental analysis characterized the degree of its purity. In addition, the antioxidant potency of chitosan derivative-glucosamine sulfate was investigated in various established in vitro systems, such as superoxide (O-2)/hydroxyl (·OH) radicals scavenging, reducing power, iron ion chelating. The following results are obtained: first, glucosamine sulfate had pronounced scavenging effect on superoxide radical. For example the O-2 scavenging activity of glucosamine sulfate was 92.11% at 0.8 mg/mL. Second, the ·OH scavenging activity of glucosamine sulfate was also strong, and was about 50% at 3.2 mg/mL. Third, the reducing power of glucosamine sulfate was more pronounced. The reducing power of glucosamine sulfate was 0.643 at 0.75 mg/mL. However, its potency for ferrous ion chelating was weak. Furthermore, except for ferrous ion chelating potency, the scavenging rate of radical and reducing power of glucosamine sulfate were concentration-dependent and increased with their increasing concentrations, but its ferrous ion chelating potency decreased with the increasing concentration. The multiple antioxidant activities of glucosamine sulfate were evidents of reducing power and superoxide/hydroxyl radicals scavenging ability. These in vitro results suggest the possibility that glucosamine sulfate could be used effectively as an ingredient in health or functional food, to alleviate oxidative stress.
关键词	glucosamine sulfate ion-exchange method radical scavenging effect reducing power chelating effect
CNKI专辑号	A;B;
CNKI专辑名称	基础科学;工程科技Ⅰ辑;
CNKI专题号	B015;B014;
CNKI专题名称	无机化工;化学;
分类号	O611
收录类别	中科院核心
语种	英文;
资助项目(基金）	Supported by the Talent Program of Chinese Academy of Sciences (Dongbei Zhi Chun) ; Award Foundation of Scientific Research for Excellent Young and Middle-Age Scientist of Shandong Province (No. 2007BS07002)
文献类型	CNKI期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/192593
专题	中国科学院海洋研究所
作者单位	1.InstituteofOceanology,ChineseAcademyofSciences 2.GraduateSchoolofChineseAcademyofSciences
推荐引用方式 GB/T 7714	Xing RE,Liu S,Wang L,et al. The preparation and antioxidant activity of glucosamine sulfate. 2009.