Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula

IOCAS-IR

	Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula
	Liu X(刘旭); Li XM(李晓明); Gao LX(高立信); Cui CM(崔传明); Li CS(李春顺); Li J(李佳); Wang BG(王斌贵)
发表期刊	Chinese Journal of Oceanology and Limnology
ISSN	0254-4059
	2011-05-15
出版年	2011
卷号	v.29 期号:03 页码:196-200
文献类型	CNKI期刊论文
摘要	Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl)methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC50 values of 3.9, 4.3, and 3.5 μmol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs.
关键词	marine alga Rhodomelaceae Symphyocladia latiuscula bromophenol protein tyrosine phosphatase 1B (PTP1B)
CNKI专辑号	A;
CNKI专辑名称	基础科学;
CNKI专题号	A006;
CNKI专题名称	生物学;
分类号	Q946
收录类别	中科院核心
语种	英文;
资助项目(基金）	Supported by the National Natural Science Foundation (No. 30530080) ; the Ministry of Science and Technology of China (Nos. 2007AA09Z402, 2007AA09Z403) ; the Department of Science and Technology of Shandong Province (No. 2006GG2205023)
文献类型	CNKI期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/191707
专题	中国科学院海洋研究所
作者单位	1.KeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences 2.GraduateUniversityofChineseAcademyofSciences 3.NationalCenterforDrugScreening,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences
推荐引用方式 GB/T 7714	Liu X,Li XM,Gao LX,et al. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula. 2011.