Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury

IOCAS-IR

	Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury
	Huang W(黄伟); Cao L(曹亮); Ye ZJ(叶振江); Lin LS(林龙山); Chen QZ(陈全震); Dou SZ(窦硕增)
发表期刊	Chinese Journal of Oceanology and Limnology
ISSN	0254-4059
	2012-07-15
出版年	2012
卷号	v.30 期号:04 页码:65-75
文献类型	CNKI期刊论文
摘要	To understand mercury (Hg) toxicity in marine fish, we measured Hg accumulation in juvenile Japanese flounder (Paralichthys olivaceus) and assessed the effects on growth and antioxidant responses. After Hg exposure (control, 5, 40, and 160 μg/L Hg) for 28 d, fish growth was significantly reduced. The accumulation of Hg in fish was dose-dependent and tissue-specific, with the maximum accumulation in kidney and liver, followed by gills, bone, and muscle. Different antioxidants responded differently to Hg exposure to cope with the induction of lipid peroxidation (LPO), which was also tissue-specific and dosedependent. As Hg concentration increased, superoxide dismutase (SOD) and catalase (CAT) activities increased significantly, whereas glutathione S-transferase (GST) activity and glutathione (GSH) levels decreased significantly in the gills. SOD and glutathione peroxidase (GPx) activities and the GSH level increased significantly in the liver. SOD activity and GSH levels increased significantly, but CAT activity decreased significantly with an increase in Hg concentration in the kidney. LPO was induced significantly by elevated Hg in the gills and kidney but was least affected in the liver. Therefore, oxidative stress biomarkers in gills were more sensitive than those in the liver and kidney to Hg exposure. Thus, the gills have potential as bioindicators for evaluating Hg toxicity in juvenile flounder.
关键词	mercury (Hg) antioxidants lipid peroxidation bioaccumulation of metal
CNKI专辑号	A;B;
CNKI专辑名称	基础科学;工程科技Ⅰ辑;
CNKI专题号	A006;B027;
CNKI专题名称	生物学;环境科学与资源利用;
分类号	X174
收录类别	中科院核心
语种	英文;
资助项目(基金）	Supported by the National Natural Science Foundation of China for Creative Research Groups (No. 41121064) ; the National High Technology Research and Development Program of China (863 Program) (No.2009AA09Z401) ; the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-YW-Q07-02) ; the Public Interest Research Program in Marine Industry from the State Oceanic Administration of China (No. 200905019)
文献类型	CNKI期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/191185
专题	中国科学院海洋研究所
作者单位	1.LaboratoryofMarineEcosystemandBiogeochemistry,SecondInstituteofOceanography,StateOceanicAdministration 2.KeyLaboratoryofMarineEcologyandEnvironmentalSciences,InstituteofOceanology,ChineseAcademyofSciences 3.FisheryCollege,OceanUniversityofChina 4.ThirdInstituteofOceanography,StateOceanicAdministration
推荐引用方式 GB/T 7714	Huang W,Cao L,Ye ZJ,et al. Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury. 2012.