Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides

doi:10.1021/np040234m

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	Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides
	Zhao, JL; Ma, M ; Wang, SJ; Li, S; Cao, P ; Yang, YC ; Lu, Y; Shi, JG ; Xu, NJ ; Fan, X ; He, L ; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
	2005-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	68 期号:5 页码:691-694
文章类型	Article
摘要	Three new bromophenols coupled with pyroglutamic acid derivatives and one bromophenol coupled with deoxyguanosine were obtained from the red alga Rhodomela confervoides. By spectroscopic methods including 2D NMR and single-crystal X-ray structure analysis their structures were elucidated as N-(2,3-dibromo-4,5-dihydroxybenzyl)methyl pyroglutamate (1), N-(2,3-dibromo-4,5-dihydroxybenzyl)pyroglutamic acid (2), N-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyllmethyl pyroglutamate (3), and 2-N-(2,3-dibromo-4,5-dihydroxybenzylamino)deoxyguanosine (4), respectively. Compounds 1-4 were evaluated against several microorganisms and human cancer cell lines, but found inactive. To our knowledge this is the first report of bromophenols coupled with amino acid or nucleoside derivatives through the C-N bond.; Three new bromophenols coupled with pyroglutamic acid derivatives and one bromophenol coupled with deoxyguanosine were obtained from the red alga Rhodomela confervoides. By spectroscopic methods including 2D NMR and single-crystal X-ray structure analysis their structures were elucidated as N-(2,3-dibromo-4,5-dihydroxybenzyl)methyl pyroglutamate (1), N-(2,3-dibromo-4,5-dihydroxybenzyl)pyroglutamic acid (2), N-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyllmethyl pyroglutamate (3), and 2-N-(2,3-dibromo-4,5-dihydroxybenzylamino)deoxyguanosine (4), respectively. Compounds 1-4 were evaluated against several microorganisms and human cancer cell lines, but found inactive. To our knowledge this is the first report of bromophenols coupled with amino acid or nucleoside derivatives through the C-N bond.
关键词	Polysiphonia-urceolata Odonthalia Corymbifera Leathesia-nana Larix
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np040234m
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000229596900010
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/1890
专题	海洋生物技术研发中心
通讯作者	Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Zhao, JL,Ma, M,Wang, SJ,et al. Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(5):691-694.
APA	Zhao, JL.,Ma, M.,Wang, SJ.,Li, S.,Cao, P.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2005).Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,68(5),691-694.
MLA	Zhao, JL,et al."Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 68.5(2005):691-694.

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