Vercytochalasins A and B: Two unprecedented biosynthetically related cytochalasins from the deep-sea-sourced endozoic fungus Curvularia verruculosa

IOCAS-IR

	Vercytochalasins A and B: Two unprecedented biosynthetically related cytochalasins from the deep-sea-sourced endozoic fungus Curvularia verruculosa
	Xueyi Hu; Xiaoming Li ; Suiqun Yang ; Xin Li; Bingui Wang; Linghong Meng
发表期刊	Chinese Chemical Letters
ISSN	1001-8417
	2023-02-15
出版年	2023
卷号	v.34 期号:02 页码:439-443
文献类型	CNKI期刊论文
摘要	Vercytochalasins A(1) and B(2), two biosynthetically related cytochalasins featuring novel structure and substituents, were isolated from the endozoic fungus Curvularia verruculosa which was associated with the deep-sea squat lobster Shinkaia crosnieri collected from the cold seep environment in South China sea. Their structures were elucidated by detailed interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations were confirmed by NOESY experiments as well as by DP4+ and ECD calculations. Differed from common cytochalasins, compound 1 is an uncommon secocytochalasin featuring the ester group cleaved between C-9 and C-23, and incorporating an additional oxygenated C4 unit which coupled with C-20 and C-22 to form a new substituted cyclohexenone moiety, while compound 2 contains an unusual 2–hydroxy-3-oxobutan-2-yl unit at C-22. Both compounds are distinctive from the commonly described cytochalasins. Compound 1 exhibited potent activity against angiotensinI-converting enzyme(ACE) whereas compound 2 showed antibacterial activity. Molecular docking simulations were performed to explore the intermolecular interaction of compounds 1 and 2 with ACE.
关键词	Deep sea Endozoic fungus Curvularia verruculosa Cytochalasins Angiotensin-I-converting enzyme inhibitory activity
CNKI专辑号	B;A;
CNKI专辑名称	工程科技Ⅰ辑;基础科学;
CNKI专题号	A006;
CNKI专题名称	生物学;
分类号	Q936
收录类别	中科院核心 ; 中科院扩展
语种	英文;
资助项目(基金）	financially supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA22050401) ; the National Natural Science Foundation of China (Nos. U2006203 and 42076090) ; the Senior User Project of RV KEXUE (No. KEXUE2020GZ02) ; and the Shandong Provincial Natural Science Foundation (No. ZR2021ZD28) ; the Basic Applied Research program of Qingdao (No. 19–6–2–40-cg) ; the support of the RV KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences (for sampling) and the Oceanographic Data center at IOCAS (for CPU time)
文献类型	CNKI期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/187188
专题	中国科学院海洋研究所
作者单位	1.CASandShandongProvinceKeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences,andLaboratoryofMarineBiologyandBiotechnology,QingdaoNationalLaboratoryforMarineScienceandTechnology 2.CollegeofMarineSciences,UniversityofChineseAcademyofSciences 3.CenterforOceanMega-Science,ChineseAcademyofSciences
推荐引用方式 GB/T 7714	Xueyi Hu,Xiaoming Li,Suiqun Yang,et al. Vercytochalasins A and B: Two unprecedented biosynthetically related cytochalasins from the deep-sea-sourced endozoic fungus Curvularia verruculosa. 2023.