The application of marine polysaccharides to antitumor nanocarriers

doi:10.1016/j.carbpol.2024.122407

IOCAS-IR > 实验海洋生物学重点实验室

	The application of marine polysaccharides to antitumor nanocarriers
	Wang, Hui1,2,3 ; Hunter, Roger 4; Zhang, Quanbin 1,3; Yu, Haoyu 1,2,3; Wang, Jing1,3 ; Yue, Yang1 ; Geng, Lihua 1; Wu, Ning 1,2,3
	2024-10-15
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	342 页码:13
通讯作者	Wu, Ning([email protected])
摘要	Nanotechnology has revolutionized the diagnosis, monitoring and treatment of biomedical diseases, in which nanocarriers have greatly improved the targeting and bioavailability of antitumor drugs. The marine natural polysaccharides fucoidan, chitosan, alginate, carrageenan and porphyran have broad-spectrum bioactivities and unique physicochemical properties such as excellent non-toxicity, biocompatibility, biodegradability and reproducibility, which have placed them as a principal focus in the nanocarrier field. Nanocarriers based on different types of marine polysaccharides are distinctive in addressing antitumor therapeutic challenges such as targeting, environmental responsiveness, drug resistance, tissue toxicity, enhancing diagnostic imaging, overcoming the first-pass effect and innovative 3D binding. Additionally, they all share the possibility of relatively easy chemical modification, while their separation into well-defined derivatives provide innovative structureactivity relationship possibilities. Liposomes, nanoparticles and polymer-micelles constructed from them can efficiently deliver drugs such as paclitaxel, gemcitabine, siRNA and others, which are widely used in radiotherapy, chemotherapy, immunotherapy, nucleic acid therapy and photothermal therapy, yet there are still infinite possibilities for innovation and exploration. This article reviews the recent advances and challenges of marine polysaccharide-based delivery systems as oncology drug nanocarriers.
关键词	Fucoidan Chitosan Alginate Carrageenan Porphyran Antitumor nanocarriers
DOI	10.1016/j.carbpol.2024.122407
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42176137]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:001259695900001
出版者	ELSEVIER SCI LTD
WOS关键词	CANCER-TREATMENT ; NANOPARTICLES ; STATISTICS ; FUCOIDAN ; CELLS ; ULVAN ; ACID
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186411
专题	实验海洋生物学重点实验室
通讯作者	Wu, Ning
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Dept Drugs & Bioprod, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Cape Town, Chem Dept, ZA-7701 Cape Town, South Africa
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Hui,Hunter, Roger,Zhang, Quanbin,et al. The application of marine polysaccharides to antitumor nanocarriers[J]. CARBOHYDRATE POLYMERS,2024,342:13.
APA	Wang, Hui.,Hunter, Roger.,Zhang, Quanbin.,Yu, Haoyu.,Wang, Jing.,...&Wu, Ning.(2024).The application of marine polysaccharides to antitumor nanocarriers.CARBOHYDRATE POLYMERS,342,13.
MLA	Wang, Hui,et al."The application of marine polysaccharides to antitumor nanocarriers".CARBOHYDRATE POLYMERS 342(2024):13.