Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity

doi:10.1016/j.ijbiomac.2024.133635

IOCAS-IR > 实验海洋生物学重点实验室

	Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity
	Xu, Gangming; Yang, Suiqun
	2024-08-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	275 页码:14
通讯作者	Xu, Gangming([email protected])
摘要	Two-component signaling systems (TCS) are the predominant means of microbes for sensing and responding to environmental stimuli. Typically, TCS is comprised of a sensor histidine kinase (HK) and a cognate response regulator (RR), which might have coevolved together. They usually involve the phosphoryl transfer signaling mechanism. However, there are also some orphan and atypical HK and RR homologs, and their evolutionary origins are still not very clear. They are not associated with cognate pairs or lack the conserved residues for phosphoryl transfer, but they could receive or respond to signals from other regulators. The objective of this study is to reveal the evolutionary history of these orphan and atypical HK and RR homologs. Structural, domain, sequence, and phylogenetic analyses indicated that their evolution process might undergo gene duplication, divergence, and domain shuffling. Meanwhile, lateral gene transfer might also be involved for their gene distribution. Evolution of orphan and atypical HK and RR homologs have increased their signaling diversity, which could be helpful for microbial adaption in complex environments.
关键词	Two-component system Histidine kinase Response regulator
DOI	10.1016/j.ijbiomac.2024.133635
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001267171600001
出版者	ELSEVIER
WOS关键词	DI-GMP RECEPTOR ; PROTEIN-KINASE ; BIOFILM FORMATION ; RECEIVER DOMAIN ; VIBRIO-CHOLERAE ; SENSOR KINASES ; NMR STRUCTURE ; BINDING ; PHOSPHORYLATION ; INSIGHTS
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186348
专题	实验海洋生物学重点实验室
通讯作者	Xu, Gangming
作者单位	Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Gangming,Yang, Suiqun. Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,275:14.
APA	Xu, Gangming,&Yang, Suiqun.(2024).Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,275,14.
MLA	Xu, Gangming,et al."Evolution of orphan and atypical histidine kinases and response regulators for microbial signaling diversity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 275(2024):14.