Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells

doi:10.1002/smll.202401772

	Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells
	Wang, Jie 1,2; Li, Ping 1; Zhang, Renshuai 1; Zhang, Miao 1; Wang, Chao 1; Zhao, Kaihua 3; Wang, Jing 2; Wang, Ning 2; Xing, Dongming 1
	2024-07-05
发表期刊	SMALL
ISSN	1613-6810
页码	12
通讯作者	Wang, Jie([email protected]) ; Wang, Ning([email protected]) ; Xing, Dongming([email protected])
摘要	Flexibility of nanomaterials is challenging but worthy to tune for biomedical applications. Biocompatible silica nanomaterials are under extensive exploration but are rarely observed to exhibit flexibility despite the polymeric nature. Herein, a facile one-step route is reported to ultrathin flexible silica nanosheets (NSs), whose low thickness and high diameter-to-thickness ratio enables folding. Thickness and diameter can be readily tuned to enable controlled flexibility. Mechanism study reveals that beyond the commonly used surfactant, the "uncommon" one bearing two hydrophobic tails play a guiding role in producing sheeted/layered/shelled structures, while addition of ethanol appropriately relieved the strong interfacial tension of the assembled surfactants, which will otherwise produce large curled sheeted structures. With these ultrathin NSs, it is further shown that the cellular preference for particle shape and rigidity is highly dependent on surface chemistry of nanoparticles: under high particle-cell affinity, NSs, and especially the flexible ones will be preferred by mammalian cells for internalization or attachment, while this preference is basically invalid when the affinity is low. Therefore, properties of the ultrathin silica NSs can be effectively expanded and empowered by surface chemistry to realize improved bio-sensing or drug delivery. Via a co-templating and interfacial tension-tuned approach, ultrathin silica nanosheets showing high and tunable flexibility are fabricated, with surface chemistry-modulated interaction with mammalian cells. image
关键词	coarse grained molecular dynamics flexibility nanoparticle-cell affinity surface chemistry ultrathin silica nanosheets
DOI	10.1002/smll.202401772
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Shandong Province[ZR2023QC090]; China Postdoctoral Science Foundation[2021T140355]; National Natural Science Foundation of China[82303590]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:001262345900001
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	NANOPARTICLES ; SPHERES ; GROWTH
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186318
专题	海洋环境腐蚀与生物污损重点实验室
通讯作者	Wang, Jie; Wang, Ning; Xing, Dongming
作者单位	1.Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Dept Breast Surg, Qingdao 266042, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Jie,Li, Ping,Zhang, Renshuai,et al. Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells[J]. SMALL,2024:12.
APA	Wang, Jie.,Li, Ping.,Zhang, Renshuai.,Zhang, Miao.,Wang, Chao.,...&Xing, Dongming.(2024).Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells.SMALL,12.
MLA	Wang, Jie,et al."Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells".SMALL (2024):12.