The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis

doi:10.3389/fphar.2024.1397761

IOCAS-IR > 实验海洋生物学重点实验室

	The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis
	Xu, Ming 1; Sun, Yu 1; Cong, Beibei 2; Zhang, Xiaopei 3; Li, Zhenfeng 4; Liu, Yingnan 1; Geng, Lihua 5; Qin, Qi 1; Wu, Yingtao 2; Gao, Meihua 2; Wang, Wanchun 2; Wang, Yuanfei 2; Xu, Yingjie2
	2024-07-22
发表期刊	FRONTIERS IN PHARMACOLOGY
卷号	15 页码:17
通讯作者	Wang, Yuanfei([email protected]) ; Xu, Yingjie([email protected])
摘要	Oral leukoplakia (OLK) is the most common oral precancerous lesion, and 3%-17% of OLK patients progress to oral squamous cell carcinoma. OLK is susceptible to recurrence and has no effective treatment. However, conventional drugs have significant side effects and limitations. Therefore, it is important to identify drugs that target OLK. In this study, scavenger receptor A (SR-A) was found to be abnormally highly expressed in the oral mucosal epithelial cells of OLK patients, whereas molecular biology studies revealed that low molecular weight fucoidan (LMWF) promoted apoptosis of dysplastic oral keratinocytes (DOK) and inhibited the growth and migration of DOK, and the inhibitory effect of LMWF on OLK was achieved by regulating the SR-A/Wnt signaling axis and related genes. Based on the above results and the special situation of the oral environment, we constructed LMWF/poly(caprolactone-co-lactide) nanofiber membranes with different structures for the in-situ treatment of OLK using electrospinning technology. The results showed that the nanofiber membranes with a shell-core structure had the best physicochemical properties, biocompatibility, and therapeutic effect, which optimized the LMWF drug delivery and ensured the effective concentration of the drug at the target point, thus achieving precise treatment of local lesions in the oral cavity. This has potential application value in inhibiting the development of OLK.
关键词	fucoidan electrospun nanofiber oral leukoplakia scavenger receptor A Wnt/beta-catenin
DOI	10.3389/fphar.2024.1397761
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China10.13039/501100001809
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:001283563700001
出版者	FRONTIERS MEDIA SA
WOS关键词	EXPRESSION ; POLYSACCHARIDES ; CLASSIFICATION ; ANTIOXIDANT ; ACTIVATION ; PATHWAY ; CANCER ; TCF4
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186178
专题	实验海洋生物学重点实验室
通讯作者	Wang, Yuanfei; Xu, Yingjie
作者单位	1.Qingdao Univ, Qingdao Med Coll, Qingdao, Peoples R China 2.Qingdao Univ, Qingdao Stomatol Hosp, Qingdao, Peoples R China 3.Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Qingdao Med Coll, Sch Basic Med,Dept Pathophysiol, Qingdao, Peoples R China 4.Weifang Med Univ, Expt Ctr Med Res, Weifang, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ming,Sun, Yu,Cong, Beibei,et al. The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis[J]. FRONTIERS IN PHARMACOLOGY,2024,15:17.
APA	Xu, Ming.,Sun, Yu.,Cong, Beibei.,Zhang, Xiaopei.,Li, Zhenfeng.,...&Xu, Yingjie.(2024).The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis.FRONTIERS IN PHARMACOLOGY,15,17.
MLA	Xu, Ming,et al."The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis".FRONTIERS IN PHARMACOLOGY 15(2024):17.