| Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides | |
| Ma, Ming; Zhao, Jielu; Wang, Sujuan; Li, Shuai; Yang, Yongchun; Shi, Jiangong; Fan, Xiao; He, Lan; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China | |
| 2007-03-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 70期号:3页码:337-341 |
| 文章类型 | Article |
| 摘要 | Three new bromophenols C-N coupled with nucleoside base derivatives (1-3) and three new brominated 1,2,3,4-tetrahydroisoquinolines (5-7, together with a new brominated tyrosine derivative (4, have been isolated from polar fractions of an ethanolic extract of the red alga Rhodomela confervoides. By spectroscopic and chemical methods including HRMS and 2D NMR data, their structures were determined as 7-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl]-3,7-dihydro-1H-purine-2,6-dione (1), 7-(2,3-dibromo-4,5-dihydroxybenzyl)-3,7-dihydro-1H-purine-2,6-dione (2, 9-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl]adenine (3), (-)-8S-(3-bromo-5-hydroxy-4-methoxy)phenylalanine (4), (-)-3S-8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (5), methyl (-)-3S-8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (6), and methyl (-)-3S-6-bromo-8-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (7). Compounds 5-7 were semisynthesized by using 4 as the starting material.; Three new bromophenols C-N coupled with nucleoside base derivatives (1-3) and three new brominated 1,2,3,4-tetrahydroisoquinolines (5-7, together with a new brominated tyrosine derivative (4, have been isolated from polar fractions of an ethanolic extract of the red alga Rhodomela confervoides. By spectroscopic and chemical methods including HRMS and 2D NMR data, their structures were determined as 7-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl]-3,7-dihydro-1H-purine-2,6-dione (1), 7-(2,3-dibromo-4,5-dihydroxybenzyl)-3,7-dihydro-1H-purine-2,6-dione (2, 9-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl]adenine (3), (-)-8S-(3-bromo-5-hydroxy-4-methoxy)phenylalanine (4), (-)-3S-8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (5), methyl (-)-3S-8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (6), and methyl (-)-3S-6-bromo-8-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (7). Compounds 5-7 were semisynthesized by using 4 as the starting material. |
| 关键词 | Alpha-amino-acids Odonthalia-floccosa 3-bromo-4-hydroxybenzaldehyde 4-hydroxybenzaldehyde Derivatives Metabolism Fractions |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np0604001 |
| URL | 查看原文 |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000245118800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/1860 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Key Lab Bioact Substances & Resources Utilizat Ch, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Ming,Zhao, Jielu,Wang, Sujuan,et al. Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(3):337-341. |
| APA | Ma, Ming.,Zhao, Jielu.,Wang, Sujuan.,Li, Shuai.,Yang, Yongchun.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2007).Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,70(3),337-341. |
| MLA | Ma, Ming,et al."Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 70.3(2007):337-341. |
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