Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242

doi:10.1016/j.bioorg.2024.107417

IOCAS-IR > 实验海洋生物学重点实验室

	Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242
	Wang, Ying1,2 ; Li, Xiao-Ming 1,2; Song, Ni 4; Wang, Bin-Gui1,2,3,5 ; Li, Hong-Lei1,2 ; Meng, Ling-Hong1,2,5
	2024-06-01
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	147 页码:10
通讯作者	Meng, Ling-Hong([email protected])
摘要	Marine natural products play an important role in biopesticides. Seven new secondary metabolites with different structural classes, including two cycloheptapeptides, scortide A (1) and scortide B (2), two 19-nor-diterpenoids, talascortene H (3) and talascortene I (4), two diterpenoid acids, talascortene J (5) and talascortene K (6), and one triterpenoid, talascortene L (7) were isolated and identified from the sea-anemone-derived endozoic fungus Talaromyces scorteus AS-242. Their structures were comprehensively assigned by spectroscopic data analysis, single-crystal X-ray diffraction, tandem mass spectrometry, and electronic circular dichroism (ECD) calculations. The result of the antimicrobial assay demonstrated that compounds 1 - 6 have inhibitory activity against several human, aquatic, and plant pathogens with minimum inhibitory concentration (MIC) values ranging from 1 to 64 mu g/mL. Specially, compounds 2 and 4 showed significant activities against the pathogenic fungus Curvularia spicifera with the MIC value of 1 mu g/mL, providing an experimental basis of 2 and 4 with the potential as lead compounds to be developed into biopesticides.
关键词	Cycloheptapeptides Terpenoids Talaromyces scorteus Antimicrobial activities Deep-sea seamount-derived fungus
DOI	10.1016/j.bioorg.2024.107417
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China (NSFC)[42176115]; National Natural Science Foundation of China (NSFC)[41976090]; Senior User Project of RV KEXUE[KEX-UE2020GZ02]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS记录号	WOS:001238098100002
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	TANDEM MASS-SPECTRA ; ABSOLUTE-CONFIGURATION ; CYCLIC HEPTAPEPTIDES ; PROLINE ; CARBON
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186063
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Wang, Ying,Li, Xiao-Ming,Song, Ni,et al. Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242[J]. BIOORGANIC CHEMISTRY,2024,147:10.
APA	Wang, Ying,Li, Xiao-Ming,Song, Ni,Wang, Bin-Gui,Li, Hong-Lei,&Meng, Ling-Hong.(2024).Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242.BIOORGANIC CHEMISTRY,147,10.
MLA	Wang, Ying,et al."Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242".BIOORGANIC CHEMISTRY 147(2024):10.