Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against <i>Meloidogyne incognita</i>

doi:10.1016/j.ijbiomac.2024.132131

IOCAS-IR > 实验海洋生物学重点实验室

	Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against Meloidogyne incognita
	Fan, Zhaoqian 1,2; Gao, Kun 1,2; Wang, Linsong 1,2; Qin, Yukun1 ; Liu, Song 1,2; Xing, Ronge1,2 ; Yu, Huahua1,2 ; Li, Kecheng 1,2; Li, Pengcheng1
	2024-06-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	269 页码:14
通讯作者	Qin, Yukun([email protected]) ; Li, Pengcheng([email protected])
摘要	Chitosan oligosaccharide (COS) modification is a feasible way to develop novel green nematicides. This study involved the synthesis of various COS sulfonamide derivatives via hydroxylated protection and deprotection, which were then characterized using NMR, FTIR, MS, elemental analysis, XRD, and TG/DTG. In vitro experiments found that COS -alkyl sulfonamide derivatives ( S6 and S11 - S13 ) exhibited high mortality ( >98 % at 1 mg/mL) against Meloidogyne incognita second-instar larvaes (J2s) among the derivatives. S6 can cause vacuole -like structures in the middle and tail regions of the nematode body and effectively inhibit egg hatching. In vivo tests have found that S6 has well control effects and low plant toxicity. Additionally, the structure -activity studies revealed that S6 with a high degree of substitution, a low molecular weight, and a sulfonyl bond on the amino group of the COS backbone exhibited increased nematicidal activity. The sulfonamide group is a potential active group for developing COS -based nematicides.
关键词	Chitosan oligosaccharide (COS) Modification Sulfonamide groups Nematicide Root-knot nematode Meloidogyne incognita
DOI	10.1016/j.ijbiomac.2024.132131
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42076126]; Shandong Provincial Natural Science Foundation[ZR2021QD090]; Shandong Provincial Natural Science Foundation[ZR2020MD072]; Shandong Provincial Natural Science Foundation[ZR2021QC006]; Shandong Provincial Natural Science Foundation[ZR2022YQ37]; China Postdoctoral Science Foundation[2019M652491]; Shandong Key R D Plan; Major Scientific and Technological Innovation Project[2022CXGC020413]; Liaoning Provincial Natural Science Founda-tion: Joint Open Fund of the State Key Laboratory for the Creation and Development of New Pesticides[2022-KF-25-03]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001240619800001
出版者	ELSEVIER
WOS关键词	ANTIBACTERIAL ACTIVITY ; BIOLOGICAL EVALUATION ; DERIVATIVES ; METABOLITES ; CHITINASE ; NEMATODES ; SURFACES ; PROTEIN
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/186018
专题	实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Fan, Zhaoqian,Gao, Kun,Wang, Linsong,et al. Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against Meloidogyne incognita[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,269:14.
APA	Fan, Zhaoqian.,Gao, Kun.,Wang, Linsong.,Qin, Yukun.,Liu, Song.,...&Li, Pengcheng.(2024).Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against Meloidogyne incognita.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,269,14.
MLA	Fan, Zhaoqian,et al."Sulfonamide modified chitosan oligosaccharide with high nematicidal activity against Meloidogyne incognita".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 269(2024):14.