Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis

doi:10.1111/mec.17352

	Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis
	Huo, Da 1,2,3,4; Liu, Shilin 1,2,3,4; Zhang, Libin 1,2,3,4; Yang, Hongsheng1,2,3,4 ; Sun, Lina 1,2,3,4,5
	2024-04-16
发表期刊	MOLECULAR ECOLOGY
ISSN	0962-1083
页码	19
通讯作者	Sun, Lina([email protected])
摘要	Low dissolved oxygen (LO) conditions represent a major environmental challenge to marine life, especially benthic animals. For these organisms, drastic declines in oxygen availability (hypoxic events) can trigger mass mortality events and thus, act as agents of selection influencing the evolution of adaptations. In sea cucumbers, one of the most successful groups of benthic invertebrates, the exposure to hypoxic conditions triggers adaptive adjustments in metabolic rates and behaviour. It is unclear, however, how these adaptive responses are regulated and the genetic mechanisms underpinning them. Here, we addressed this knowledge gap by assessing the genetic regulation (transcription and translation) of hypoxia exposure in the sea cucumber Apostichopus japonicus. Transcriptional and translational gene expression profiles under short- and long-term exposure to low oxygen conditions are tightly associated with extracellular matrix (ECM)-receptor interaction in which laminin and collagen likely have important functions. Finding revealed that genes with a high translational efficiency (TE) had a relatively short upstream open reading frame (uORF) and a high uORF normalized minimal free energy, suggesting that sea cucumbers may respond to hypoxic stress via altered TE. These results provide valuable insights into the regulatory mechanisms that confer adaptive capacity to holothurians to survive oxygen deficiency conditions and may also be used to inform the development of strategies for mitigating the harmful effects of hypoxia on other marine invertebrates facing similar challenges.
关键词	Apostichopus japonicus ribosome profiling RNA-seq transcriptional regulation translational efficiency translational regulation
DOI	10.1111/mec.17352
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China; Shandong Provincial Natural Science Foundation[ZR2021QD013]; National Key R&D Program of China[2022YFF0802202]; Postdoctoral Innovative Talents Support Program of Shandong Province[SDBX2020006]; Special Research Assistant Project of Chinese Academy of Sciences; Taishan Scholars Program (Youth Taishan Scholars)[tsqn202306287]; [42261160378]; [42106106]
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:001203102200001
出版者	WILEY
WOS关键词	CUCUMBER APOSTICHOPUS-JAPONICUS ; RIBOSOME PROFILING REVEALS ; GENOME-WIDE ANALYSIS ; GENE-EXPRESSION ; BASEMENT-MEMBRANES ; RESPIRATORY TREE ; IN-VIVO ; LAMININ ; COLLAGEN ; LANDSCAPE
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185131
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Huo, Da,Liu, Shilin,Zhang, Libin,et al. Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis[J]. MOLECULAR ECOLOGY,2024:19.
APA	Huo, Da,Liu, Shilin,Zhang, Libin,Yang, Hongsheng,&Sun, Lina.(2024).Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis.MOLECULAR ECOLOGY,19.
MLA	Huo, Da,et al."Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis".MOLECULAR ECOLOGY (2024):19.