| Proteasome and NF-kappa B inhibiting phaeophytins from the green alga Cladophora fascicularis | |
| Huang, Xinping; Li, Min; Xu, Bo; Zhu, Xiaobin; Deng, Zhiwei; Lin, Wenhan; Li, M, Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China | |
| 2007-03-01 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 12期号:3页码:582-592 |
| 文章类型 | Article |
| 摘要 | Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-alpha) induced nuclear factor-kappa B (NF-kappa B) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.; Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-alpha) induced nuclear factor-kappa B (NF-kappa B) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed. |
| 关键词 | Green Alga Cladophora Fascicularis Porphyrinolactone Nf-kappa b Proteasome |
| 学科领域 | Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245437400028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/1848 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Li, M, Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China |
| 作者单位 | 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100073, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xinping,Li, Min,Xu, Bo,et al. Proteasome and NF-kappa B inhibiting phaeophytins from the green alga Cladophora fascicularis[J]. MOLECULES,2007,12(3):582-592. |
| APA | Huang, Xinping.,Li, Min.,Xu, Bo.,Zhu, Xiaobin.,Deng, Zhiwei.,...&Li, M, Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China.(2007).Proteasome and NF-kappa B inhibiting phaeophytins from the green alga Cladophora fascicularis.MOLECULES,12(3),582-592. |
| MLA | Huang, Xinping,et al."Proteasome and NF-kappa B inhibiting phaeophytins from the green alga Cladophora fascicularis".MOLECULES 12.3(2007):582-592. |
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