Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325

doi:10.1016/j.phytochem.2024.114000

IOCAS-IR > 实验海洋生物学重点实验室

	Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325
	Wang, Yi-Ran1,2,3 ; Dong, Yu-Liang 1,2; Li, Xiao-Ming 1,2; Shi, Xiao-Shan1 ; Meng, Ling-Hong1,2,3 ; Xu, Rui1 ; Wang, Bin-Gui1,2,3,4
	2024-04-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	220 页码:7
通讯作者	Wang, Bin-Gui([email protected])
摘要	Sumalarins D-G (1-4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 mu g/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC50 values of 3.5, 10.6, 10.9, and 14.9 mu M, respectively.
关键词	Marine-derived fungus Mangrove plant Penicillium sumatrense Curvularin derivatives Antimicrobial and cytotoxic activities
DOI	10.1016/j.phytochem.2024.114000
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31570356]
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号	WOS:001178000100001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	METABOLITES ; RHIZOSPHERE ; POLYKETIDE
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184838
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Yi-Ran,Dong, Yu-Liang,Li, Xiao-Ming,et al. Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325[J]. PHYTOCHEMISTRY,2024,220:7.
APA	Wang, Yi-Ran.,Dong, Yu-Liang.,Li, Xiao-Ming.,Shi, Xiao-Shan.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2024).Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325.PHYTOCHEMISTRY,220,7.
MLA	Wang, Yi-Ran,et al."Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325".PHYTOCHEMISTRY 220(2024):7.