Effects of toxin metalloproteinases from jellyfish<i> Nemopilema</i><i> nomurai</i> nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis

doi:10.1016/j.intimp.2024.111492

IOCAS-IR > 实验海洋生物学重点实验室

	Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis
	Li, Aoyu 1,2,3; Yu, Huahua1,2 ; Li, Rongfeng 1,2; Yue, Yang1 ; Yu, Chunlin1,2 ; Liu, Song 1,2; Xing, Ronge1,2 ; Li, Pengcheng1,2
	2024-02-15
发表期刊	INTERNATIONAL IMMUNOPHARMACOLOGY
ISSN	1567-5769
卷号	128 页码:12
通讯作者	Yu, Huahua([email protected])
摘要	Jellyfish dermatitis is a common medical problem in many countries due to the jellyfish envenomation. However, there are no specific and targeted medications for their treatment. Here we investigated the possible therapeutic effects of metalloproteinase inhibitors on the dermal toxicity of Nemopilema nomurai nematocyst venom (NnNV), a giant venomous jellyfish from China, using the jellyfish dermatitis model, focusing on inflammatory effector molecules during jellyfish envenomation. Metalloproteinase may further stimulate inflammation by promoting oxidative stress in the organism and play key roles by activating MAPK and NF-kappa B, in the pathogenesis of jellyfish dermatitis. And the metalloproteinase inhibitors batimastat and EDTA disodium salt may treat the Jellyfish dermatitis by inhibiting the metalloproteinase activity in NnNV. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to dermal toxicity as the inflammation effect molecular, and metalloproteinase inhibitors can be regarded as novel therapeutic medicines in jellyfish envenomation. This study contributes to understanding the mechanism of jellyfish dermatitis and suggests new targets and ideas for the treatment of jellyfish envenomation.
关键词	Inflammation Jellyfish dermatitis Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Metalloproteinase
DOI	10.1016/j.intimp.2024.111492
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[41776163]; National Key R&D Program of China[41876164]; Natural Sci-ence Foundation of Shandong Province[2019YFC0312605]; Natural Sci-ence Foundation of Shandong Province[2017YFE0111100-04]; [ZR2019QD012]
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001165303400001
出版者	ELSEVIER
WOS关键词	RHOPILEMA-ESCULENTUM ; OXIDATIVE STRESS ; VENOM ; STINGS ; MANAGEMENT ; INHIBITOR ; DISCHARGE ; CNIDARIA ; BLOOMS
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184563
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,128:12.
APA	Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2024).Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis.INTERNATIONAL IMMUNOPHARMACOLOGY,128,12.
MLA	Li, Aoyu,et al."Effects of toxin metalloproteinases from jellyfish Nemopilema nomurai nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis".INTERNATIONAL IMMUNOPHARMACOLOGY 128(2024):12.