Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus

doi:10.1016/j.ecoenv.2023.115558

	Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus
	Ding, Kui1,2,3 ; Xu, Qinzeng 1,2; Zhang, Xuelei 1,2; Liu, Shilin 3
	2023-11-01
发表期刊	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN	0147-6513
卷号	266 页码:11
通讯作者	Ding, Kui([email protected])
摘要	The persistent organic pollutant 2,2 ',4,4 '-Tetrabromodiphenyl ether (BDE-47), a prevalent congener among polybrominated diphenyl ethers (PBDEs), exhibits potent bioaccumulation and toxicity. Despite extensive research into the adverse effects of BDE-47, its neurotoxicity in sea cucumbers remains unexplored. Given the crucial role of the sea cucumber's nervous system in survival and adaptation, evaluating the impacts of BDE-47 is vital for sustainable aquaculture and consumption. In this study, we employed ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS) to analyze metabolomic changes in neuro-related tissues of Apostichopus japonicus exposed to low (0.1 mu g/L), medium (1.0 mu g/L), and high (10.0 mu g/L) BDE-47 concentrations. We identified significantly changed metabolites in each exposure group (87 in low, 79 in medium, and 102 in high), affecting a variety of physiological processes such as steroid hormone balance, nucleotide metabolism, energy metabolism, neurotransmitter levels, and neuroprotection. In addition, we identified concentration-dependent, common, and some other metabolic responses in the neuro-related tissues. Our findings reveal critical insights into the neurotoxic effects of BDE-47 in sea cucumbers and contribute to risk assessment related to BDE-47 exposure in the sea cucumber industry, paving the way for future neurotoxicological research in invertebrates.
关键词	Apostichopus japonicus BDE-47 Nervous system UPLC-Triple-TOF-MS Metabolite Neurotoxicity
DOI	10.1016/j.ecoenv.2023.115558
收录类别	SCI
语种	英语
资助项目	National Natural Science Founda-tion of China[42106131]
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS类目	Environmental Sciences ; Toxicology
WOS记录号	WOS:001095010000001
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; NEONATAL EXPOSURE ; ACID-METABOLISM ; SERINE RACEMASE ; IMMUNE FUNCTION ; VITAMIN-A ; BEHAVIOR
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183844
专题	海洋生态与环境科学重点实验室
通讯作者	Ding, Kui
作者单位	1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao 266061, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266061, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室
通讯作者单位	海洋生态与环境科学重点实验室
推荐引用方式 GB/T 7714	Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,et al. Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2023,266:11.
APA	Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,&Liu, Shilin.(2023).Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,266,11.
MLA	Ding, Kui,et al."Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 266(2023):11.

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