Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection

doi:10.1016/j.celrep.2023.112414

IOCAS-IR > 实验海洋生物学重点实验室

	Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection
	Qin, Kunpeng 1,2,3; Jiang, Shuai 1,2,3; Xu, Hang1,2,3 ; Yuan, Zihao1,2 ; Sun, Li 1,2,3
	2023-05-30
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	42 期号:5 页码:18
通讯作者	Jiang, Shuai([email protected]) ; Sun, Li([email protected])
摘要	Gasdermin (GSDM) is a family of proteins that execute pyroptosis in vertebrate. In invertebrate, pyroptotic GSDM was documented only in coral. Recent studies identified abundant GSDM structural homologs in Mol-lusca, but their functions are unclear. Herein, we report a functional GSDM from Pacific abalone Haliotis discus (HdGSDME). HdGSDME is specifically activated by abalone caspase 3 (HdCASP3) cleavage at two distinct sites, generating two active isoforms with pyroptotic and cytotoxic activities. HdGSDME possesses evolution-arily conserved residues that proved to be essential to the N-terminal pore-formation and C-terminal auto -in-hibition capacities. Bacterial challenge activates the HdCASP3-HdGSDME pathway and induces pyroptosis and extracellular traps in abalone. Blockage of the HdCASP3-HdGSDME axis promotes bacterial invasion and host mortality. Collectively, this study reveals the existence of functionally conserved and yet distinct -featured GSDM in Mollusca and provides insights into the function and evolution of invertebrate GSDM.
DOI	10.1016/j.celrep.2023.112414
收录类别	SCI
语种	英语
资助项目	Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203000]; Youth Innovation Promotion Association CAS[2021204]; National Key Research and Development Project of China[2018YFD0900500]; Taishan Scholar Program of Shandong Province
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000986046500001
出版者	CELL PRESS
WOS关键词	CELL-DEATH ; INFLAMMASOME ; CASPASES ; CLEAVAGE ; EVOLUTION ; GENOME ; FAMILY ; OYSTER ; GSDMD
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182961
专题	实验海洋生物学重点实验室
通讯作者	Jiang, Shuai; Sun, Li
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Qin, Kunpeng,Jiang, Shuai,Xu, Hang,et al. Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection[J]. CELL REPORTS,2023,42(5):18.
APA	Qin, Kunpeng,Jiang, Shuai,Xu, Hang,Yuan, Zihao,&Sun, Li.(2023).Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection.CELL REPORTS,42(5),18.
MLA	Qin, Kunpeng,et al."Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection".CELL REPORTS 42.5(2023):18.