Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)

doi:10.1016/j.dsr.2023.104114

IOCAS-IR > 实验海洋生物学重点实验室

	Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)
	Chen, Xiao-Dan 1,2,3; Yang, Sui-Qun 1,2,4; Li, Xiao-Ming 1,2,4; Wang, Bin-Gui1,2,3,4,5 ; Li, Xin1,2,4,5
	2023-09-01
发表期刊	DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
ISSN	0967-0637
卷号	199 页码:7
通讯作者	Wang, Bin-Gui([email protected]) ; Li, Xin([email protected])
摘要	Three new secondary metabolites, including a new polyketide, acrefurcatone A (1), a new ascochlorin analogue, acremochlorin N (2), and 3-phenylcyclopentane-1,2-diol (& PLUSMN;-3), a pair of new naturally occurring enantiomers, along with nine known ascochlorins (4-12), were identified from Furcasterigmium furcatum CS-280 (syn. Acremonium furcatum CS-280), a fungus isolated from the deep-sea cold-seep sediment samples collected in the South China Sea. Their structures were determined by detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative configurations of compounds 1-3 were assigned by NOESY correlations combined with gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis, while their absolute configurations were assigned by time-dependent density functional (TDDFT) ECD calculations and specific rotation calculations. Compound 1 exhibited potent activity against the human pathogenic bacterium Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) value of 8 & mu;g/mL. The isolated ascochlorins also showed potent activities against aquatic bacteria, especially for Vibrio harveyi and V. alginolyticus, with MIC values comparable to chloramphenicol. Analysis of the structure-activity relationship indicated that the cinnamate derivative, such as compound 1, or the presence of chlorine atom in ascochlorin derivatives, such as compounds 4, 6, and 7, significantly enhanced the antibacterial activities. This is the first report of anti-Vibrio activities for ascochlorin derivatives.
关键词	Cold seep Furcasterigmium furcatum Acremonium furcatum Polyketides Ascochlorins Antibacterial activity
DOI	10.1016/j.dsr.2023.104114
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U2006203]; National Natural Science Foundation of China[42076090]; National Natural Science Foundation of China[KEXUE2020GZ02]; Senior User Project of RV KEXUE[ZR2021ZD28]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]; RV KEXUE of the National Major Science and Technology Infrastructure from Chinese Academy of Sciences; Oceanographic Data Center at IOCAS; [82003648]
WOS研究方向	Oceanography
WOS类目	Oceanography
WOS记录号	WOS:001055658900001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	METABOLITES ; INHIBITOR
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182841
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xin
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Chen, Xiao-Dan,Yang, Sui-Qun,Li, Xiao-Ming,et al. Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)[J]. DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,2023,199:7.
APA	Chen, Xiao-Dan,Yang, Sui-Qun,Li, Xiao-Ming,Wang, Bin-Gui,&Li, Xin.(2023).Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum).DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,199,7.
MLA	Chen, Xiao-Dan,et al."Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)".DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS 199(2023):7.