Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts

doi:10.3390/md21050293

IOCAS-IR > 实验海洋生物学重点实验室

	Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts
	Dong, Yu-Liang 1,2,3,4; Li, Xiao-Ming 1,2,3,5; Shi, Xiao-Shan1,2 ; Wang, Yi-Ran1,2,3,4 ; Wang, Bin-Gui1,2,3,4,5 ; Meng, Ling-Hong1,2,3,4,5
	2023-05-10
发表期刊	MARINE DRUGS
卷号	21 期号:5 页码:10
通讯作者	Wang, Bin-Gui([email protected]) ; Meng, Ling-Hong([email protected])
摘要	Two new quinazolinone diketopiperazine alkaloids, including versicomide E (2) and cottoquinazoline H (4), together with ten known compounds (1, 3, and 5-12) were isolated and identified from Aspergillus versicolor AS-212, an endozoic fungus associated with the deep-sea coral Hemicorallium cf. imperiale, which was collected from the Magellan Seamounts. Their chemical structures were determined by an extensive interpretation of the spectroscopic and X-ray crystallographic data as well as specific rotation calculation, ECD calculation, and comparison of their ECD spectra. The absolute configurations of ()-isoversicomide A (1) and cottoquinazoline A (3) were not assigned in the literature reports and were solved in the present work by single-crystal X-ray diffraction analysis. In the antibacterial assays, compound 3 exhibited antibacterial activity against aquatic pathogenic bacteria Aeromonas hydrophilia with an MIC value of 18.6 mu M, while compounds 4 and 8 exhibited inhibitory effects against Vibrio harveyi and V. parahaemolyticus with MIC values ranging from 9.0 to 18.1 mu M.
关键词	diketopiperazine Aspergillus versicolor deep-sea coral endophytic fungus antimicrobial activity
DOI	10.3390/md21050293
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U2006203]; National Natural Science Foundation of China[41976090]; Senior User Project of RV KEXUE[KEXUE2020GZ02]; Shandong Provincial Natural Science Foundation[ZR2021ZD28]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:001033226700001
出版者	MDPI
WOS关键词	METABOLITES ; ANTIFUNGAL ; STRAIN
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182727
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Dong, Yu-Liang,Li, Xiao-Ming,Shi, Xiao-Shan,et al. Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts[J]. MARINE DRUGS,2023,21(5):10.
APA	Dong, Yu-Liang,Li, Xiao-Ming,Shi, Xiao-Shan,Wang, Yi-Ran,Wang, Bin-Gui,&Meng, Ling-Hong.(2023).Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts.MARINE DRUGS,21(5),10.
MLA	Dong, Yu-Liang,et al."Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts".MARINE DRUGS 21.5(2023):10.