Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice

doi:10.1007/s00343-022-2225-8

IOCAS-IR > 实验海洋生物学重点实验室

	Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice
	Tan, Jiaojiao 1,2,3; Song, Yimin 4; Wang, Jing1 ; Wu, Ning 1,5,6; Yue, Yang1 ; Zhang, Quanbin 1,2
	2023-07-29
发表期刊	JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	2096-5508
页码	10
通讯作者	Wu, Ning([email protected]) ; Zhang, Quanbin([email protected])
摘要	The brown seaweed, Sacchairna japonica, has been used in traditional Chinese medicine for over one thousand years. Oral administration of fucoidan or low molecular weight fucoidan (LMWF) from S. japonica could ameliorate kidney dysfunction in chronic kidney diseases and inhibit diabetic vascular complications. In many studies, LMWF was found to be more potent than fucoidan with high molecular weight. However, the pharmacokinetics of LMWF still remains unclear. The purpose of the research is to compare the pharmacokinetics of fucoidan with high molecular weight (136 kDa) with that low molecular weight (9.5 kDa) after oral administration to ICR mice. Since fucose is the main and representative monosaccharide of fucoidans, we evaluate the pharmacokinetics of fucoidan and LMWF by determining the fucose concentration in mice serum. Both fucoidan and LMWF were absorbed following oral administration. Fucoidan and LMWF were provided to mice by oral administration with 60 mg/kg and the maximum Concentration (C-max) was found at 2.5 h (0.66 & PLUSMN;0.32 mg/L) for Fucoidan and 1.5 h (1.01 & PLUSMN;0.56 mg/L) for LMWF, respectively. It seems that LMWF had a higher area under the curve (AUC(0-t)) and was absorbed more quickly than fucoidan. The estimated bioavailability of LMWF was 28.3% in the mice treated with a single dose of 30 mg/kg. In addition, LMWF was found widely spreaded into different tissues following oral administration and the highest concentration was found in kidney at 19.93 & PLUSMN;7.02 & mu;g/g. In this study, we first studied the pharmacokinetics of LMWF, in order to help to understand the function of LMWF. And our results shed light on the potential of development of drugs based on LMWF.
关键词	fucoidan low molecular weight fucoidan pharmacokinetics bioavailability tissue distribution
DOI	10.1007/s00343-022-2225-8
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42176137]; National Natural Science Foundation of China[81872906]; Nantong Science and Technology Project[MS12021037]; STS Program of Chinese Academy of Sciences[KFJ-STS-QYZD-195]; K. C. Wong Education Foundation; CAS~
WOS研究方向	Marine & Freshwater Biology ; Oceanography
WOS类目	Limnology ; Oceanography
WOS记录号	WOS:001039209600001
出版者	SCIENCE PRESS
WOS关键词	SULFATED POLYSACCHARIDE ; ANTICOAGULANT ACTIVITY ; ANTIOXIDANT ACTIVITY ; INJURY
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182706
专题	实验海洋生物学重点实验室
通讯作者	Wu, Ning; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Univ Sci & Technol, Dept Pharmaceut Engn, Qingdao 266000, Peoples R China 5.Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Biol Prod, Qingdao 266237, Peoples R China 6.Nantong Zhongke Marine Sci & Technol Res & Dev Ctr, Nantong 226000, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Tan, Jiaojiao,Song, Yimin,Wang, Jing,et al. Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2023:10.
APA	Tan, Jiaojiao,Song, Yimin,Wang, Jing,Wu, Ning,Yue, Yang,&Zhang, Quanbin.(2023).Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,10.
MLA	Tan, Jiaojiao,et al."Pharmacokinetics of fucoidan and low molecular weight fucoidan from Saccharina japonica after oral administration to mice".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2023):10.