Oxepine-containing pyrazinopyrimidine alkaloids and quinolinone derivatives produced by Aspergillus versicolor AS-212, a deep-sea-derived endozoic fungus

doi:10.1016/j.fitote.2023.105559

IOCAS-IR > 实验海洋生物学重点实验室

	Oxepine-containing pyrazinopyrimidine alkaloids and quinolinone derivatives produced by Aspergillus versicolor AS-212, a deep-sea-derived endozoic fungus
	Dong, Yu-Liang 1; Li, Xiao-Ming ; Wang, Yi-Ran1 ; Shi, Xiao-Shan; Wang, Bin-Gui1,2,3,4 ; Meng, Ling-Hong1,2
	2023-07-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	168 页码:6
通讯作者	Wang, Bin-Gui([email protected]) ; Meng, Ling-Hong([email protected])
摘要	Four new oxepine-containing pyrazinopyrimidine alkaloids, versicoxepines A -D (1-4), two quinolinone alkaloid analogs including 3-hydroxy-6-methoxy-4-phenylquinolin-2(1H)-one (5) and 3-methoxy-6-hydroxy-4-phenylquinolin-2(1H)-one (6) which were new naturally occurring compounds, together with two known compounds (7 and 8) were isolated from Aspergillus versicolor AS-212, an endozoic fungus isolated from the deep-sea coral Hemicorallium cf. imperiale, which was collected from the Magellan Seamounts in the Western Pacific Ocean. Their structures were determined by extensive analysis of the spectroscopic and X-ray crystallographic data as well as by chiral HPLC analysis, ECD calculation, and DP4+ probability prediction. Structurally, versi-coxepines B and C (2 and 3) represent the first example of a new oxepine-containing pyrazinopyrimidine alkaloid whose cyclic dipeptide moiety is composed of the same type of amino acid (Val or Ile). Compound 5 displayed antibacterial activity against aquatic pathogens, Vibrio harveyi and V. alginolyticus, with MICs of 8 & mu;g/mL.
关键词	Pyrazinopyrimidine alkaloid Aspergillus versicolor Deep-sea coral Endozoic fungus Antimicrobial activity
DOI	10.1016/j.fitote.2023.105559
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U2006203]; National Natural Science Foundation of China[41976090]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]; Shandong Provincial Natural Science Foundation[KEXUE2020GZ02]; Oceanographic Data Center at IOCAS; Senior User Project of RV KEXUE; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences; [ZR2021ZD28]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:001020680900001
出版者	ELSEVIER
WOS关键词	ANTIFUNGAL
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182428
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Dong, Yu-Liang,Li, Xiao-Ming,Wang, Yi-Ran,et al. Oxepine-containing pyrazinopyrimidine alkaloids and quinolinone derivatives produced by Aspergillus versicolor AS-212, a deep-sea-derived endozoic fungus[J]. FITOTERAPIA,2023,168:6.
APA	Dong, Yu-Liang,Li, Xiao-Ming,Wang, Yi-Ran,Shi, Xiao-Shan,Wang, Bin-Gui,&Meng, Ling-Hong.(2023).Oxepine-containing pyrazinopyrimidine alkaloids and quinolinone derivatives produced by Aspergillus versicolor AS-212, a deep-sea-derived endozoic fungus.FITOTERAPIA,168,6.
MLA	Dong, Yu-Liang,et al."Oxepine-containing pyrazinopyrimidine alkaloids and quinolinone derivatives produced by Aspergillus versicolor AS-212, a deep-sea-derived endozoic fungus".FITOTERAPIA 168(2023):6.