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Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles
Chen, Xuelian1; Liu, Lijia2; Shen, Chen1; Liu, Fangyan1; Xu, Enyu1; Chen, Yin1; Jie, Wang1
2023-05-30
发表期刊POLYMERS
卷号15期号:11页码:16
通讯作者Jie, Wang([email protected])
摘要In recent years, natural polysaccharides have been widely used in the preparation of drug delivery systems. In this paper, novel polysaccharide-based nanoparticles were prepared by layer-by-layer assembly technology using silica as a template. The layers of nanoparticles were constructed based on the electrostatic interaction between a new pectin named NPGP and chitosan (CS). The targeting ability of nanoparticles was formed by grafting the RGD peptide, a tri-peptide motif containing arginine, glycine, and aspartic acid with high affinity to integrin receptors. The layer-by-layer assembly nanoparticles (RGD-(NPGP/CS)(3)NPGP) exhibited a high encapsulation efficiency (83.23 +/- 6.12%), loading capacity (76.51 +/- 1.24%), and pH-sensitive release property for doxorubicin. The RGD-(NPGP/CS)(3)NPGP nanoparticles showed better targeting to HCT-116 cells, the integrin alpha v beta 3 high expression human colonic epithelial tumor cell line with higher uptake efficiency than MCF7 cells, the human breast carcinoma cell line with normal integrin expression. In vitro antitumor activity tests showed that the doxorubicin-loaded nanoparticles could effectively inhibit the proliferation of the HCT-116 cells. In conclusion, RGD-(NPGP/CS)(3)NPGP nanoparticles have potential as novel anticancer drug carriers because of their good targeting and drug-carrying activity.
关键词layer-by-layer nanoparticle polysaccharide
DOI10.3390/polym15112510
收录类别SCI
语种英语
资助项目National Natural Science Foundation of Zhejiang Province, China[LTGS23D060001]
WOS研究方向Polymer Science
WOS类目Polymer Science
WOS记录号WOS:001003459100001
出版者MDPI
WOS关键词HOLLOW NANOCAPSULES ; RELEASE
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/182294
专题实验海洋生物学重点实验室
通讯作者Jie, Wang
作者单位1.Zhejiang Ocean Univ, Coll Food & Pharm, Zhoushan 316000, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
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GB/T 7714
Chen, Xuelian,Liu, Lijia,Shen, Chen,et al. Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles[J]. POLYMERS,2023,15(11):16.
APA Chen, Xuelian.,Liu, Lijia.,Shen, Chen.,Liu, Fangyan.,Xu, Enyu.,...&Jie, Wang.(2023).Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles.POLYMERS,15(11),16.
MLA Chen, Xuelian,et al."Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles".POLYMERS 15.11(2023):16.
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