Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique <i>p</i>-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512

doi:10.1021/acs.jafc.3c02610

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	Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512
	Chi, Lu-Ping1,2,3 ; Liu, Dong 1,2; Li, Xiao-Ming 1,2; Wan, Yupeng 1,2; Wang, Bin-Gui1,2,4 ; Li, Xin1,2,4
	2023-08-31
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	71 期号:36 页码:13316-13324
通讯作者	Wang, Bin-Gui([email protected]) ; Li, Xin([email protected])
摘要	Marine fungus-derived natural products are an important source of antimicrobial compounds against marine aquatic pathogens. Here, we describe the isolation and characterization of five new pentadepsipeptides, aspertides A-E (1-5), containing a unique p-methoxycinnamoyl amide group, from the marine fungi Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Among them, aspertides B-E (2-5) also possessed uncommon amino acid residues, such as 3-hydroxyproline, 2,3-dihydroxyproline, or pipecolinic acid. The structures of these compounds were elucidated on the basis of NMR and mass spectroscopic analyses. The absolute configurations of them were established by chiral HPLC analyses of the acidic hydrolysates and NMR calculations with DP4+ probability analysis. In bio-activity assays, compounds 4 and 5 exhibited antibacterial activities against aquatic-pathogenic bacteria, including Edwardsiella tarda, Vibrio alginolyticus, Vibrio anguillarum, Vibrio vulnificus, and Staphylococcus aureus, with MIC values of 8-32 mu g/mL.
关键词	marine-derivedfungi pentadepsipeptides p-methoxycinnamoylamide Aspergillus spp. antimicrobial activity
DOI	10.1021/acs.jafc.3c02610
收录类别	SCI
语种	英语
资助项目	This work was financially supported by the National Key Ramp;amp;D Program of China (2022YFC2804700), the National Natural Science Foundation of China (32200022, 42076090, and U2006203), and the Shandong Provincial Natural Science Foundation (ZR2021ZD28).
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号	WOS:001060974700001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181809
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xin
作者单位	1.Chinese Acad Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,et al. Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(36):13316-13324.
APA	Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,Wan, Yupeng,Wang, Bin-Gui,&Li, Xin.(2023).Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(36),13316-13324.
MLA	Chi, Lu-Ping,et al."Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.36(2023):13316-13324.