Evolutionary history of the NLR gene families across lophotrochozoans

doi:10.1016/j.gene.2022.146807

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	Evolutionary history of the NLR gene families across lophotrochozoans
	Zhu, Xiaofei 1,2,3,4,5; Mu, Kang3,4,5,6 ; Wan, Yi ; Zhang, Linlin 2,3,4,5,6
	2022-11-15
发表期刊	GENE
ISSN	0378-1119
卷号	843 页码:10
通讯作者	Zhang, Linlin([email protected])
摘要	NOD-like receptor (NLR) genes are critical innate immune receptors in animals and plants. Lophotrochozoans represent one of the most species-rich superphyla that includes molluscs, segmented worms, flatworms, bryo-zoans, and other invertebrates, which is crucial to our understanding of immune system evolution in bilaterians. However, NLRs have not been systematically described in lophotrochozoans. We annotated 185 NLRs in 29 lophotrochozoan genomes, and analyzed their domain organization, phylogenetic distribution, molecular evo-lution, and gene expression. We found that all the 24 molluscan genomes studied encoded no more than three NLRs. None of these molluscan NLRs represented an inducible expression pattern under the infection of eight pathogens; some molluscan NLRs showed developmental stage-specific expression patterns. Instead, 29 molluscan incomplete NLR (incNLR) genes, encoding for proteins absent in the NACHT domain were upregulated under pathogen infection. We also documented the species-specific expansion of NLRs in the clades Polychaeta and Pteriidae. Our study revealed that gene duplication, domain shuffling, gene loss, and novel expression pattern played important roles in the molecular evolution of NLRs.
关键词	NLR Lophotrochozoan Expansion Gene expression Innate immunity
DOI	10.1016/j.gene.2022.146807
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41976088]; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42000000]; Key Development Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Science[COMS2019R01]; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)[2022QNLM030004]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000848450000004
出版者	ELSEVIER
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180931
专题	实验海洋生物学重点实验室深海极端环境与生命过程研究中心
通讯作者	Zhang, Linlin
作者单位	1.Hainan Univ, State Key Lab Marine Resource Utilizat South China, Haikou, Peoples R China 2.Chinese Acad Sci, Qingdao, Peoples R China 3.Chinese Acad Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Ctr Ocean Mega Sci, Qingdao, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	深海极端环境与生命过程研究中心
通讯作者单位	深海极端环境与生命过程研究中心
推荐引用方式 GB/T 7714	Zhu, Xiaofei,Mu, Kang,Wan, Yi,et al. Evolutionary history of the NLR gene families across lophotrochozoans[J]. GENE,2022,843:10.
APA	Zhu, Xiaofei,Mu, Kang,Wan, Yi,&Zhang, Linlin.(2022).Evolutionary history of the NLR gene families across lophotrochozoans.GENE,843,10.
MLA	Zhu, Xiaofei,et al."Evolutionary history of the NLR gene families across lophotrochozoans".GENE 843(2022):10.

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1-s2.0-S037811192200（1946KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览