A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians

doi:10.3390/biology11081095

	A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians
	Su, Fang1,2,3,4,5,6 ; Yang, Hongsheng1,2,3,4,5,6,7 ; Sun, Lina 1,2,3,4,5,6
	2022-08-01
发表期刊	BIOLOGY-BASEL
卷号	11 期号:8 页码:15
通讯作者	Sun, Lina([email protected])
摘要	Simple Summary Many species of sea cucumber in Echinodermata may eviscerate most of or even all internal organs when encountering predators or adverse environments, and can achieve regeneration within a certain time. Although regeneration time varies, the mechanism is common. This paper reviewed the intestinal regeneration process of sea cucumbers from the perspectives of histocytology and molecular mechanism. Echinodermata has a special evolutionary position between achordate and chordate, so we hope to explore the common regeneration conserved signals between invertebrates and vertebrates by recording the intestinal regeneration of sea cucumbers. Most species of the class Holothuroidea are able to regenerate most of their internal organs following a typical evisceration process, which is a unique mechanism that allows sea cucumbers to survive in adverse environments. In this review, we compare autotomy among different type of sea cucumber and summarize the histocytological events that occur during the five stages of intestinal regeneration. Multiple cytological activities, such as apoptosis and dedifferentiation, take place during wound healing and anlage formation. Many studies have focused on the molecular regulation mechanisms that underlie regeneration, and herein we describe the techniques that have been used as well as the development-related signaling pathways and key genes that are significantly expressed during intestinal regeneration. Future analyses of the underlying mechanisms responsible for intestinal regeneration should include mapping at the single-cell level. Studies of visceral regeneration in echinoderms provide a unique perspective for understanding whole-body regeneration or appendage regeneration.
关键词	sea cucumber evisceration regeneration holothurian echinoderm
DOI	10.3390/biology11081095
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42076093]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000846947600001
出版者	MDPI
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180910
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 7.Chinese Acad Sci, Innovat Seed Design, Wuhan 430071, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋大科学研究中心; 中国科学院海洋研究所
通讯作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋大科学研究中心; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Su, Fang,Yang, Hongsheng,Sun, Lina. A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians[J]. BIOLOGY-BASEL,2022,11(8):15.
APA	Su, Fang,Yang, Hongsheng,&Sun, Lina.(2022).A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians.BIOLOGY-BASEL,11(8),15.
MLA	Su, Fang,et al."A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians".BIOLOGY-BASEL 11.8(2022):15.