Different antigen ratio in bivalent vaccine can affect immunological activation and protection against Aeromonas salmonicida and Vibrio anguillarum in Atlantic salmon

doi:10.1016/j.fsi.2022.08.033

IOCAS-IR

	Different antigen ratio in bivalent vaccine can affect immunological activation and protection against Aeromonas salmonicida and Vibrio anguillarum in Atlantic salmon
	Kuang, Baozhi 1; Xiao, Kun 2; Wang, Wenqi 1; You, Feng 2; Xiao, Peng 2; Chen, Shiyong 1
	2022-09-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	128 页码:644-650
通讯作者	Xiao, Peng([email protected]) ; Chen, Shiyong([email protected])
摘要	To effectively prevent the outbreak of furunculosis and vibriosis in Atlantic salmon culture in northern China, the immunological properties and efficacies of bivalent inactivated vaccines composed of two local pathogenic strains, Aeromonas salmonicida C4 and Vibrio anguillarum M3, was analyzed in salmon. The effect of formalin-inactivated A. salmonicida C4, V. anguillarum M3, and their combined vaccines with different antigen ratio of 1:1, 1:2 and 2:1 on relative percentage of survival (RPS), specific antibody production and expression of immune -related genes of fish were investigated. It was found that both C4 and M3 antigen had adjuvant effects on each other???s vaccines. Furthermore, the proportion of antigens in the combined vaccines had significantly different effects on immune response and protection against A. salmonicida or V. anguillarum infection. Compared with other vaccinated groups, the C4:M3 = 1:2 vaccine group had the highest immunological activation ability and best immune protection against A. salmonicida and V. anguillarum. Our studies suggest that the development of new multivalent vaccines should carefully design the ratio of different antigens in according to their immuno-logical properties to achieve efficient protection and avoid inhibitory effects of antigens on specific pathogen. Superscript/Subscript Available
关键词	Bivalent vaccine Aeromonas salmonicida Vibrio anguillarum Atlantic salmon
DOI	10.1016/j.fsi.2022.08.033
收录类别	SCI
语种	英语
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:000859699700009
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180751
专题	中国科学院海洋研究所
通讯作者	Xiao, Peng; Chen, Shiyong
作者单位	1.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Kuang, Baozhi,Xiao, Kun,Wang, Wenqi,et al. Different antigen ratio in bivalent vaccine can affect immunological activation and protection against Aeromonas salmonicida and Vibrio anguillarum in Atlantic salmon[J]. FISH & SHELLFISH IMMUNOLOGY,2022,128:644-650.
APA	Kuang, Baozhi,Xiao, Kun,Wang, Wenqi,You, Feng,Xiao, Peng,&Chen, Shiyong.(2022).Different antigen ratio in bivalent vaccine can affect immunological activation and protection against Aeromonas salmonicida and Vibrio anguillarum in Atlantic salmon.FISH & SHELLFISH IMMUNOLOGY,128,644-650.
MLA	Kuang, Baozhi,et al."Different antigen ratio in bivalent vaccine can affect immunological activation and protection against Aeromonas salmonicida and Vibrio anguillarum in Atlantic salmon".FISH & SHELLFISH IMMUNOLOGY 128(2022):644-650.