Hemocytes of bivalve mollusks as cellular models in toxicological studies of metals and metal-based nanomaterials

doi:10.1016/j.envpol.2022.120082

IOCAS-IR > 实验海洋生物学重点实验室

	Hemocytes of bivalve mollusks as cellular models in toxicological studies of metals and metal-based nanomaterials
	Weng, Nanyan 1; Meng, Jie2 ; Huo, Shouliang 1; Wu, Fengchang 1; Wang, Wen-Xiong 3,4,5
	2022-11-01
发表期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
卷号	312 页码:14
通讯作者	Wang, Wen-Xiong([email protected])
摘要	Understanding the impacts of environmental pollutants on immune systems is indispensable in ecological and health risk assessments due to the significance of normal immunological functions in all living organisms. Bi-valves as sentinel organisms with vital ecological importance are widely distributed in aquatic environments and their innate immune systems are the sensitive targets of environmental pollutants. As the central component of innate immunity, bivalve hemocytes are endowed with specialized endolysosomal systems for particle inter-nalization and metal detoxification. These intrinsic biological features make them a unique cellular model for metal-and nano-immunotoxicology research. In this review, we firstly provided a general overview of bivalve's innate immunity and the classification and immune functions of hemocytes. We then summarized the recent progress on the interactions of metals and nanoparticles with bivalve hemocytes, with emphasis on the involvement of hemocytes in metal regulation and detoxification, the interactions of hemocytes and nano -particles at eco/bio-nano interface and hemocyte-mediated immune responses to the exposure of metals and nanoparticles. Finally, we proposed the key knowledge gaps and future research priorities in deciphering the fundamental biological processes of the interactions of environmental pollutants with the innate immune system of bivalves as well as in developing bivalve hemocytes into a promising cellular model for nano-immuno-safety assessment.
关键词	Bivalves Hemocytes Metals Nanoparticles Immunity
DOI	10.1016/j.envpol.2022.120082
收录类别	SCI
语种	英语
资助项目	National Natural Science Founda-tion of China[42107302]; Hong Kong Research Grants Council[CityU 16102918]; Hong Kong Research Grants Council[11102321]; Hong Kong Research Grants Council[T21-604/19-R]; Shenzhen Municipal Science and Technology Innovation Com-mission[JCYJ20210324134000001]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000862238200001
出版者	ELSEVIER SCI LTD
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180694
专题	实验海洋生物学重点实验室
通讯作者	Wang, Wen-Xiong
作者单位	1.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.City Univ Hong Kong, Sch Energy & Environm, Kowloon, Hong Kong, Peoples R China 4.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 5.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
推荐引用方式 GB/T 7714	Weng, Nanyan,Meng, Jie,Huo, Shouliang,et al. Hemocytes of bivalve mollusks as cellular models in toxicological studies of metals and metal-based nanomaterials[J]. ENVIRONMENTAL POLLUTION,2022,312:14.
APA	Weng, Nanyan,Meng, Jie,Huo, Shouliang,Wu, Fengchang,&Wang, Wen-Xiong.(2022).Hemocytes of bivalve mollusks as cellular models in toxicological studies of metals and metal-based nanomaterials.ENVIRONMENTAL POLLUTION,312,14.
MLA	Weng, Nanyan,et al."Hemocytes of bivalve mollusks as cellular models in toxicological studies of metals and metal-based nanomaterials".ENVIRONMENTAL POLLUTION 312(2022):14.

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