Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model

doi:10.1007/s10499-022-00999-0

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	Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model
	Wang, Xiaoqing 1,2; Wei, Maosheng 1,2; Wang, Jing1,3 ; Liu, Jing1,4 ; Zhang, Quanbin 1,3
	2022-10-19
发表期刊	AQUACULTURE INTERNATIONAL
ISSN	0967-6120
页码	17
通讯作者	Liu, Jing([email protected])
摘要	Many carbohydrate compounds derived from marine seaweeds possess immune-enhancing activities. In recent years, the effect of dietary addition of marine polysaccharides on fish has been widely evaluated. Here, we studied the immunoregulation potential of oligo-porphyran (OP) through LPS-induced RAW264.7 cells and zebrafish model. Surprisingly, we found that OP had an excellent anti-inflammatory effect with a dose-dependent manner in vitro. OP administration effectively reduced LPS-induced NO release and inflammatory cytokine production in RAW264.7 cells. Notably, we also found that dietary OP to zebrafish exerted positive effect on intestinal immunity through regulating immune factor content and gut microbiota. Besides, dietary OP could also maintain steadiness of intestinal morphology of zebrafish, enhance the intestinal digestive enzyme activity, and promote the accumulation of crude protein and crude fat in zebrafish. These findings indicated that OP supplementation in diet could promote growth, improve immunity, and regulate intestinal flora, which made OP a promising aquatic candidate additive.
关键词	Oligo-porphyran Immunological parameters RAW264 7 macrophages Zebrafish model
DOI	10.1007/s10499-022-00999-0
收录类别	SCI
语种	英语
资助项目	National Key research and Development Program of China[2019YFD0900705]
WOS研究方向	Fisheries
WOS类目	Fisheries
WOS记录号	WOS:000870108800001
出版者	SPRINGER
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180636
专题	实验海洋生物学重点实验室
通讯作者	Liu, Jing
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Qingdao, Peoples R China
第一作者单位	中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,et al. Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model[J]. AQUACULTURE INTERNATIONAL,2022:17.
APA	Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,Liu, Jing,&Zhang, Quanbin.(2022).Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model.AQUACULTURE INTERNATIONAL,17.
MLA	Wang, Xiaoqing,et al."Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model".AQUACULTURE INTERNATIONAL (2022):17.

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