Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324

doi:10.1021/acs.jnatprod.2c00211

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	Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324
	Hu, Xue-Yi1,2,3 ; Li, Xiao-Ming 1,2; Wang, Bin-Gui1,2,3,4 ; Meng, Ling-Hong1,2,4
	2022-05-27
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	85 期号:5 页码:1398-1406
通讯作者	Wang, Bin-Gui([email protected]) ; Meng, Ling-Hong()
摘要	Ten new tanzawaic acids, namely, steckwaic acids A-D (1-4), 11-ketotanzawaic acid D (5), 6,15-dihydroxytanzawaic acid M (6), 15R-methoxytanzawaic acid M (7), 15S-methoxytanzawaic acid M (8), 8-hydroxytanzawaic acid M (9), and 8-hydroxytanzawaic acid B (10), together with four known analogues (11-14), were isolated and identified from the endozoic fungus Penicillium steckii AS-324, which was obtained from a deep-sea Acanthogorgiidae sp. coral that was collected from the Magellan seamount in the Western Pacific Ocean. Structurally, steckwaic acids A-D (1-4) represent the first tanzawaic acid derivatives containing a naphthalene ring. Their structures were elucidated by detailed interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis and ECD calculations confirmed their structures and absolute configurations. New compounds 1, 5, and 9 exhibited activities against aquatic pathogenic bacteria Micrococcus luteus, Vibrio anguillarum, and Pseudomonas aeruginosa with MICs of 2, 4, and 4 mu g/mL, respectively.
DOI	10.1021/acs.jnatprod.2c00211
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41976090]; National Natural Science Foundation of China[42176115]; Natural Science Foundation of Jiangsu Province[BK20201211]; Natural Science Foundation of Jiangsu Province[KEXUE2020GZ02]; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000806554600022
出版者	AMER CHEMICAL SOC
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179462
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,et al. Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(5):1398-1406.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324.JOURNAL OF NATURAL PRODUCTS,85(5),1398-1406.
MLA	Hu, Xue-Yi,et al."Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324".JOURNAL OF NATURAL PRODUCTS 85.5(2022):1398-1406.

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