Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom

doi:10.1016/j.biopha.2022.113192

IOCAS-IR > 实验海洋生物学重点实验室

	Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom
	Li, Aoyu 1,2,3; Yu, Huahua1,2 ; Li, Rongfeng 1,2; Yue, Yang1,2 ; Yu, Chunlin1,2,3 ; Geng, Hao 1,2,3; Liu, Song 1,2; Xing, Ronge1,2 ; Li, Pengcheng1,2
	2022-07-01
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	151 页码:8
通讯作者	Yu, Huahua([email protected])
摘要	Jellyfish envenomation is a common medical problem in many countries. However, the myotoxicity and effector molecules of scyphozoan venoms remain uninvestigated. Here, we present the myotoxicity of nematocyst venom from Nemopilema nomurai (NnNV), a giant venomous scyphozoan from China, for the first time, using in vivo models with inhibitors. NnNV was able to induce remarkable myotoxicity including significant muscle swelling, increasing the content of CK and LDH in serum, stimulating inflammation of muscle tissue, and destroying the structure of muscle tissue. In addition, the metalloproteinase inhibitors BMT and EDTA significantly reduced the myotoxicity induced by NnNV. Moreover, BMT and EDTA could decrease the inflammatory stimulation and necrosis of muscle tissue caused by the venom. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to myotoxicity. This study contributes to understanding the effector molecules of muscle injury caused by jellyfish stings and suggests a new idea for the treatment of scyphozoan envenomation.
关键词	Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Myotoxicity Metalloprotease
DOI	10.1016/j.biopha.2022.113192
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2017YFE0111100-04]; National Key R&D Program of China[2019YFC0312605]; National Natural Sci-ence Foundation of China[41776163]; National Natural Sci-ence Foundation of China[41876164]; Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220]; Natural Science Foundation of Shandong Province[ZR2019QD012]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:000807392900004
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179435
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,151:8.
APA	Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2022).Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom.BIOMEDICINE & PHARMACOTHERAPY,151,8.
MLA	Li, Aoyu,et al."Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom".BIOMEDICINE & PHARMACOTHERAPY 151(2022):8.

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