Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br

doi:10.1021/acs.orglett.2c00781

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	Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br
	Yan, Li-Hong 1,2,3,4; Li, Pei-Hai 5; Li, Xiao-Ming 1,2,3; Yang, Sui-Qun 1,2,3; Liu, Ke-Chun 5; Wang, Bin-Gui1,2,3,4 ; Li, Xin1,2,3
	2022-04-15
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	24 期号:14 页码:2684-2688
通讯作者	Wang, Bin-Gui([email protected]) ; Li, Xin([email protected])
摘要	Chevalinulins A (1)andB(2), two indolediketopiperazine alkaloids containing an unprecedented spiro-[bicyclo[2.2.2]octane-diketopiperazine] skeleton, together with aknown analogue neoechinulin B (3), were isolated from the deep-sea cold-seep-derived fungusAspergillus chevalieriCS-122. Theirstructures were determined by spectroscopic analysis, single-crystalX-ray diffraction, specific rotation (SR), and NMR calculations.Compounds1and2exhibited significantin vivoproangiogenicactivity in transgenic zebrafish.
DOI	10.1021/acs.orglett.2c00781
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42076090]; National Natural Science Foundation of China[U2006203]; Senior User Project of RV KEXUE[KEXUE2020GZ02]; National Key R&D Program of China[2018YFC0310800]; Shandong Provincial Natural Science Foundation[ZR2021ZD28]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000791817200020
出版者	AMER CHEMICAL SOC
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179171
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xin
作者单位	1.Chinese Acad Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 5.Qilu Univ Technol, Engn Res Ctr Zebrafish Models Human Dis & Drug Sc, Biol Inst,Key Lab Biosensor Shandong Prov, Shandong Acad Sci,Shandong Prov Engn Lab Biol Tes, Jinan 250103, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yan, Li-Hong,Li, Pei-Hai,Li, Xiao-Ming,et al. Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br[J]. ORGANIC LETTERS,2022,24(14):2684-2688.
APA	Yan, Li-Hong.,Li, Pei-Hai.,Li, Xiao-Ming.,Yang, Sui-Qun.,Liu, Ke-Chun.,...&Li, Xin.(2022).Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br.ORGANIC LETTERS,24(14),2684-2688.
MLA	Yan, Li-Hong,et al."Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br".ORGANIC LETTERS 24.14(2022):2684-2688.

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