The Role of Insulin-like Peptide in Maintaining Hemolymph Glucose Homeostasis in the Pacific White Shrimp Litopenaeus vannamei

doi:10.3390/ijms23063268

IOCAS-IR > 实验海洋生物学重点实验室

	The Role of Insulin-like Peptide in Maintaining Hemolymph Glucose Homeostasis in the Pacific White Shrimp Litopenaeus vannamei
	Su, Manwen1,2,3,4 ; Zhang, Xiaojun 1,2,3,4; Yuan, Jianbo 1,2,3,4; Zhang, Xiaoxi1,2,3,4 ; Li, Fuhua 1,2,3,4
	2022-03-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	23 期号:6 页码:15
通讯作者	Zhang, Xiaojun([email protected])
摘要	Insulin-like peptide (ILP) has been identified in various crustaceans, but whether it has a similar function in regulating hemolymph glucose as vertebrate insulin is unclear. We analyzed the components of hemolymph sugar in the Pacific white shrimp, Litopenaeus vannamei, and investigated the changes of hemolymph glucose concentration and the expressions of ILP and glucose metabolism genes under different treatments. We found glucose was a major component of hemolymph sugar in shrimp. Starvation caused hemolymph glucose to rise first and then decline, and the raised hemolymph glucose after exogenous glucose injection returned to basal levels within a short time, indicating that shrimp have a regulatory mechanism to maintain hemolymph glucose homeostasis. In addition, injections of bovine insulin and recombinant LvILP protein both resulted in a fast decline in hemolymph glucose. Notably, RNA interference of LvILP did not significantly affect hemolymph glucose levels, but it inhibited exogenous glucose clearance. Based on the detection of glucose metabolism genes, we found LvILP might maintain hemolymph glucose stability by regulating the expression of these genes. These results suggest that ILP has a conserved function in shrimp similar to insulin in vertebrates and plays an important role in maintaining hemolymph glucose homeostasis.
关键词	Litopenaeus vannamei insulin-like peptide hemolymph glucose homeostasis glucose metabolism genes
DOI	10.3390/ijms23063268
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China; National Key Research& Development Program of China[31972782]; National Key Research& Development Program of China[2018 YFD0900103]; National Key Research& Development Program of China[2018 YFD0900404]; National Key Research& Development Program of China[41876167]; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105]; China Agriculture Research system-48[CARS-48]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000775350900001
出版者	MDPI
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178601
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Xiaojun
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Su, Manwen,Zhang, Xiaojun,Yuan, Jianbo,et al. The Role of Insulin-like Peptide in Maintaining Hemolymph Glucose Homeostasis in the Pacific White Shrimp Litopenaeus vannamei[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(6):15.
APA	Su, Manwen,Zhang, Xiaojun,Yuan, Jianbo,Zhang, Xiaoxi,&Li, Fuhua.(2022).The Role of Insulin-like Peptide in Maintaining Hemolymph Glucose Homeostasis in the Pacific White Shrimp Litopenaeus vannamei.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(6),15.
MLA	Su, Manwen,et al."The Role of Insulin-like Peptide in Maintaining Hemolymph Glucose Homeostasis in the Pacific White Shrimp Litopenaeus vannamei".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.6(2022):15.

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