Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach

doi:10.1016/j.scitotenv.2021.151172

	Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach
	Hu, Zhi 1,2,3,4,5; Feng, Jie 1,2,3,4; Song, Hao 1,2,3,4; Zhou, Cong1,2,3,4,5 ; Yang, Mei-Jie 1,2,3,4; Shi, Pu1,2,3,4,5 ; Yu, Zheng-Lin 6; Guo, Yong-Jun 7; Li, Yong-Ren 7; Zhang, Tao1,2,3,4
	2022-02-25
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
卷号	809 页码:12
通讯作者	Zhang, Tao([email protected])
摘要	In the context of global climatic changes, marine organisms have been exposed to environmental stressors including heat and hypoxia. This calls for the design of multi-stressors to uncover the impact of oceanic factors on aquatic organisms. So far, little is known about the metabolic response of marine organisms, especially bivalves, to the combined effects of heat and hypoxia. In this study, we employed widely targeted metabolomic analysis to study the metabolic response of gills in hard clam, a heat- and hypoxia-tolerant bivalve. A total of 810 metabolites were identified. Results showed that the heat group (HT) and heat plus hypoxia group (HL) had a higher number of differential metabolites than the hypoxia group (LO). Glycolysis was affected by the heat and heat plus hypoxia stress. Moreover, anaerobic metabolic biomarkers were accumulated marking the onset of anaerobic metabolism. Environmental stresses may affect Tricarboxylic acid (TCA) cycle. Accumulation of carnitine and glycerophospholipid may promote fatty acid beta oxidation and maintain cell membrane stability, respectively. The high content of oxidized lipids (i.e., Leukotriene) in HL and HT groups implied that the organisms were under ROS stress. The significantly differential metabolites of organic osmolytes and vitamins might relieve ROS stress. Moreover, accumulation of thermoprotective osmolytes (monosaccharide, Trimethylamine N-oxide (TMAO)) accumulation was helpful to maintain protein homeostasis. This investigation provided new insights into the adaptation mechanisms of hard clam to heat, hypoxia and combined stress at the metabolite level and highlighted the roles of molecules and protectants. (C) 2021 Published by Elsevier B.V.
关键词	Mercenaria mercenaria Metabolome Heat Hypoxia Stress
DOI	10.1016/j.scitotenv.2021.151172
收录类别	SCI
语种	英语
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000755050800005
出版者	ELSEVIER
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178090
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang, Tao
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 7.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin 300384, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋大科学研究中心; 中国科学院海洋研究所
通讯作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋大科学研究中心; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Hu, Zhi,Feng, Jie,Song, Hao,et al. Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,809:12.
APA	Hu, Zhi.,Feng, Jie.,Song, Hao.,Zhou, Cong.,Yang, Mei-Jie.,...&Zhang, Tao.(2022).Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach.SCIENCE OF THE TOTAL ENVIRONMENT,809,12.
MLA	Hu, Zhi,et al."Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach".SCIENCE OF THE TOTAL ENVIRONMENT 809(2022):12.

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