Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406

doi:10.3390/md20010004

IOCAS-IR > 实验海洋生物学重点实验室

	Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406
	Yan, Li-Hong1,2,3 ; Li, Xiao-Ming 1,2,4; Chi, Lu-Ping1,2,3 ; Li, Xin1,2,4 ; Wang, Bin-Gui1,2,3,4
	2022
发表期刊	MARINE DRUGS
卷号	20 期号:1 页码:14
通讯作者	Li, Xin([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Six new metabolites, including a pair of inseparable mixtures of secofumitremorgins A (1a) and B (1b), which differed in the configuration of the nitrogen atom, 29-hydroxyfumiquinazoline C (6), 10R-15-methylpseurotin A (7), 1,4,23-trihydroxy-hopane-22,30-diol (10), and sphingofungin I (11), together with six known compounds (2-5 and 8-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Their structures were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis of the acidic hydrolysate, X-ray crystallographic analysis, J-based configuration analysis, and quantum chemical calculations of ECD, OR, and NMR (with DP4+ probability analysis). Among the compounds, 1a/1b represent a pair of novel scaffolds derived from indole diketopiperazine by cleavage of the amide bond following aromatization to give a pyridine ring. Compounds 1, 4, 6, 7, 10 and 11 showed inhibitory activities against pathogenic bacteria and plant pathogenic fungus, with MIC values ranging from 4 to 64 mu g/mL.
关键词	Aspergillus fumigatus deep-sea sediment-derived fungus alkaloids triterpenoid antimicrobial activity
DOI	10.3390/md20010004
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDA22050401]; National Natural Science Foundation of China[42076090]; National Natural Science Foundation of China[U2006203]; Senior User Project of RV KEXUE[KEXUE2020GZ02]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]; Shandong Provincial Natural Science Foundation[ZR2021ZD28]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000758744500001
出版者	MDPI
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178030
专题	实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yan, Li-Hong,Li, Xiao-Ming,Chi, Lu-Ping,et al. Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406[J]. MARINE DRUGS,2022,20(1):14.
APA	Yan, Li-Hong,Li, Xiao-Ming,Chi, Lu-Ping,Li, Xin,&Wang, Bin-Gui.(2022).Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406.MARINE DRUGS,20(1),14.
MLA	Yan, Li-Hong,et al."Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406".MARINE DRUGS 20.1(2022):14.

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