Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides

doi:10.1016/j.algal.2021.102312

IOCAS-IR > 实验海洋生物学重点实验室

	Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides
	Li, Ke 1,2; Li, Xiao-Ming 1; Gloer, James B.3; Wang, Bin-Gui1,2,4
	2021-06-01
发表期刊	ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
ISSN	2211-9264
卷号	56 页码:5
通讯作者	Li, Ke([email protected]) ; Wang, Bin-Gui([email protected])
摘要	An extensive investigation on the chemical components with potential antioxidant activity resulted in the characterization of four new ureidobromophenols (1-4) and two related metabolites (5 and 6) from ethyl acetate extract of the marine red alga Rhodomela confervoides. Their structures were determined using spectroscopic analysis and comparisons with known compounds. Compound 1 possesses unique structure of an ureido group bearing gamma-butyric acid and 2,3-dibromo-4,5-dihydroxybenzyl moieties on the same nitrogen atom. Compounds 1-4 displayed significant antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with IC50 values ranging from 3.34 to 4.84 mu M, which are more active than that of the positive controls ascorbic acid (IC50 = 20.1 mu M) and butylated hydroxytoluene (IC50 = 82.1 mu M). These compounds also exhibited potent activity against 2,2' -azino-bis(3-ethylbenzothiazoline-6-sulphonate (ABTS) radicals with trolox equivalent antioxidant capacity (TEAC) values ranging from 3.25 to 5.01 mM, which are 3- to 5-fold potent than that of ascorbic acid (TEAC = 1.02 mM). The antioxidant activity of ureidobromophenols isolated from marine alga might boost the seaweed functional food ingredients or dietary food supplements in food industry.
关键词	Marine red alga Rhodomela confervoides Ureidobromophenols Antioxidant activity
DOI	10.1016/j.algal.2021.102312
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[31330009]; Shuangbai Plan of Yantai Municipal City[20183]; Taishan Scholar Project from Shandong Province of China
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000663410100019
出版者	ELSEVIER
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176874
专题	实验海洋生物学重点实验室
通讯作者	Li, Ke; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Inst Oceanol,Lab Marine Biol & Biotechnol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Univ Iowa, Dept Chem, Iowa City, IA 52242 USA 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Ke,Li, Xiao-Ming,Gloer, James B.,et al. Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2021,56:5.
APA	Li, Ke,Li, Xiao-Ming,Gloer, James B.,&Wang, Bin-Gui.(2021).Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,56,5.
MLA	Li, Ke,et al."Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 56(2021):5.

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